Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole genome sequencing with histopathological features

Extension of prostate cancer beyond the primary site into the surrounding organs by local invasion or nodal metastasis is associated with poor prognosis. The emergence and evolution of cancer clones at this early stage of expansion and spread has not been studied in detail. We performed whole genome...

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Bibliographic Details
Published in:	bioRxiv
Main Authors:	Srinivasa Rao Rao, Verrill, Clare, Cerundolo, Lucia, Nasullah Khalid Alham, Kaya, Zeynep, O'hanlon, Miriam, Hayes, Alicia, Lambert, Adam, James, Martha, Tullis, Iain D C, Niederer, Jane, Lovell, Shelagh, Altan Omer, Lopez, Francisco, Leslie, Tom, Buffa, Francesca M, Bryant, Richard John, Lamb, Alastair D, Vojnovic, Boris, Wedge, David C, Mills, Ian G, Woodcock, Dan J, Tomlinson, Ian Pm, Hamdy, Freddie C
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 27.02.2023 Cold Spring Harbor Laboratory
Edition:	1.2
Subjects:	Adenocarcinoma Cancer Biology Copy number Evolution Genetic transformation Genomes Lymph nodes Lymphatic system Metastases Metastasis Morphology Prostate cancer Prostatectomy Seminal vesicle Tumors Vesicles Whole genome sequencing
ISSN:	2692-8205, 2692-8205
Online Access:	Get full text
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