An improved catalogue for whole-genome sequencing prediction of bedaquiline resistance in M. tuberculosis using a reproducible algorithmic approach

Objectives: Bedaquiline (BDQ) has only been approved for use for a little over a decade yet is a key drug for treating multi-drug resistant tuberculosis. Rising levels of resistance threaten, however, to reduce its effectiveness. Catalogues of mutations associated with resistance to bedaquiline are...

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Bibliographic Details

Published in:	bioRxiv
Main Authors:	Adlard, Dylan, Lavania, Joseph, Webster, Hermione, O'reilly, Ailva, Knaggs, Jeff, Peto, Timothy Ea, Crook, Derrick W, Shaheed Vally Omar, Fowler, Philip W
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 25.02.2025 Cold Spring Harbor Laboratory
Edition:	3.1
Subjects:	Drug resistance Genetic diversity Genomes Microbiology Multidrug resistance Tuberculosis Whole genome sequencing
ISSN:	2692-8205, 2692-8205
Online Access:	Get full text
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