The integrated stress response induces R-loops and hinders replication fork progression

The integrated stress response (ISR) allows cells to rapidly shut down most of their protein synthesis in response to protein misfolding, amino acid deficiency, or virus infection. These stresses trigger the phosphorylation of the translation initiation factor eIF2alpha, which prevents the initiatio...

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Bibliographic Details
Published in:	bioRxiv
Main Authors:	Josephine Ann Mun Yee Choo, Schloesser, Denise, Manzini, Valentina, Magerhans, Anna, Dobbelstein, Matthias
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 11.03.2020 Cold Spring Harbor Laboratory
Edition:	1.1
Subjects:	Amino acids Cancer Biology Deoxyribonucleic acid DNA DNA biosynthesis Hybrids Phosphorylation Protein biosynthesis Protein deficiency Protein folding Protein synthesis Proteins R-loops Replication forks Ribonucleic acid RNA Shutdowns Translation GCN2 Thapsigargin DNA replication histones Integrated stress response PKR ISRIB PERK eIF2alpha R-loops BEPP DNA fiber assays
ISSN:	2692-8205, 2692-8205
Online Access:	Get full text
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