Characterization of Nucleotide Misincorporation Patterns in the Iceman's Mitochondrial DNA

The degradation of DNA represents one of the main issues in the genetic analysis of archeological specimens. In the recent years, a particular kind of post-mortem DNA modification giving rise to nucleotide misincorporation ("miscoding lesions") has been the object of extensive investigatio...

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Vydáno v:	PloS one Ročník 5; číslo 1; s. e8629
Hlavní autoři:	Olivieri, Cristina, Ermini, Luca, Rizzi, Ermanno, Corti, Giorgio, Bonnal, Raoul, Luciani, Stefania, Marota, Isolina, De Bellis, Gianluca, Rollo, Franco
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 08.01.2010 Public Library of Science (PLoS)
Témata:	Adenine Analysis Archaeology Contaminants Copy number Cytochrome Cytosine Deoxyribonucleic acid DNA DNA damage DNA polymerase DNA sequencing DNA, Mitochondrial - genetics Enzymes Evolutionary Biology/Genomics Evolutionary Biology/Human Evolution Fossils Freezing Gene sequencing Genetic analysis Genetic research Genetics and Genomics Guanine Historic artifacts Historic buildings & sites Human remains Humans Lesions Mitochondrial DNA Next-generation sequencing Nucleotide sequence Nucleotides - metabolism Paleontology Phylogeny Polymerase chain reaction Purines Pyrimidines Thripidae Thrips tabaci Thymine Thysanoptera Trends
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
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