Epigenetic Regulation of Inflammatory Cytokines and Associated Genes in Human Malignancies

Inflammation is a multifaceted defense response of immune system against infection. Chronic inflammation has been implicated as an imminent threat for major human malignancies and is directly linked to various steps involved in tumorigenesis. Inflammatory cytokines, interleukins, interferons, transf...

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Published in:Mediators of Inflammation Vol. 2015; no. 2015; pp. 655 - 662-059
Main Authors: Abbasi, Rashda, Khan, Abdul Rehman, Hassan, Amjad, Siraj, Sami, Yasmin, Rehana, Ahmad, Nafees
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Limiteds 01.01.2015
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Wiley
Subjects:
AC133 Antigen
Angiogenesis
Antigens, CD - genetics
Cancer
Cancer therapies
Chemokines
Chemokines - genetics
Chromatin
Cytokines
Cytokines - genetics
Deoxyribonucleic acid
Development and progression
DNA
DNA Methylation
Enzymes
Epigenesis, Genetic
Epigenetic inheritance
Epigenetics
Gene expression
Gene Expression Regulation, Neoplastic
Genetic engineering
Glycoproteins - genetics
Health aspects
Humans
Inflammation
Interferons - genetics
Interleukins - genetics
Metastasis
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - immunology
Peptides - genetics
Physiological aspects
Physiological research
Review
Suppressor of Cytokine Signaling 1 Protein
Suppressor of Cytokine Signaling Proteins - genetics
Tumor necrosis factor-TNF
Tumors
ISSN:0962-9351, 1466-1861, 1466-1861
Online Access:Get full text
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Summary:Inflammation is a multifaceted defense response of immune system against infection. Chronic inflammation has been implicated as an imminent threat for major human malignancies and is directly linked to various steps involved in tumorigenesis. Inflammatory cytokines, interleukins, interferons, transforming growth factors, chemokines, and adhesion molecules have been associated with chronic inflammation. Numerous cytokines are reported to be aberrantly regulated by different epigenetic mechanisms like DNA methylation and histone modifications in tumor tissues, contributing to pathogenesis of tumor in multiple ways. Some of these cytokines also work as epigenetic regulators of other crucial genes in tumor biology, either directly or indirectly. Such regulations are reported in lung, breast, cervical, gastric, colorectal, pancreatic, prostate, and head and neck cancers. Epigenetics of inflammatory mediators in cancer is currently subject of extensive research. These investigations may help in understanding cancer biology and to develop effective therapeutic strategies. The purpose of this paper is to have a brief view of the aberrant regulation of inflammatory cytokines in human malignancies.
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Academic Editor: Marc Pouliot
ISSN:0962-9351
1466-1861
1466-1861
DOI:10.1155/2015/201703