The Possible Clinical Predictors of Fatigue in Parkinson’s Disease: A Study of 135 Patients as Part of International Nonmotor Scale Validation Project

Fatigue is a common yet poorly understood and underresearched nonmotor symptom in Parkinson's disease. Although fatigue is recognized to significantly affect health-related quality of life, it remains underrecognised and empirically treated. In this paper, the prevalence of fatigue as measured...

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Veröffentlicht in:Parkinson's disease Jg. 2011; H. 2011; S. 20 - 26
Hauptverfasser: Barone, P., Stocchi, Fabrizio, Antonini, Angelo, Chaudhuri, K. Ray, Martin, Anne, Kaluarachchi, T. K., Schartau, P. E. S., Gage, Heather M., Martinez-Martin, Pablo, Logishetty, Kartik, Metta, Vinod, Odin, Per
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Sprache:Englisch
Veröffentlicht: Cairo, Egypt Hindawi Limiteds 01.01.2011
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Clinical Study
ISSN:2042-0080, 2090-8083, 2042-0080
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Abstract Fatigue is a common yet poorly understood and underresearched nonmotor symptom in Parkinson's disease. Although fatigue is recognized to significantly affect health-related quality of life, it remains underrecognised and empirically treated. In this paper, the prevalence of fatigue as measured by a validated visual analogue scale and the Parkinson's disease nonmotor symptoms scale (PDNMSS) was correlated with other motor and nonmotor comorbidities. In a cohort of patients from a range of disease stages, occurrence of fatigue correlated closely with more advanced Parkinson's disease, as well as with depression, anxiety, and sleep disorders, hinting at a common underlying basis.
AbstractList Fatigue is a common yet poorly understood and underresearched nonmotor symptom in Parkinson's disease. Although fatigue is recognized to significantly affect health-related quality of life, it remains underrecognised and empirically treated. In this paper, the prevalence of fatigue as measured by a validated visual analogue scale and the Parkinson's disease nonmotor symptoms scale (PDNMSS) was correlated with other motor and nonmotor comorbidities. In a cohort of patients from a range of disease stages, occurrence of fatigue correlated closely with more advanced Parkinson's disease, as well as with depression, anxiety, and sleep disorders, hinting at a common underlying basis.
Fatigue is a common yet poorly understood and underresearched nonmotor symptom in Parkinson's disease. Although fatigue is recognized to significantly affect health-related quality of life, it remains underrecognised and empirically treated. In this paper, the prevalence of fatigue as measured by a validated visual analogue scale and the Parkinson's disease nonmotor symptoms scale (PDNMSS) was correlated with other motor and nonmotor comorbidities. In a cohort of patients from a range of disease stages, occurrence of fatigue correlated closely with more advanced Parkinson's disease, as well as with depression, anxiety, and sleep disorders, hinting at a common underlying basis.Fatigue is a common yet poorly understood and underresearched nonmotor symptom in Parkinson's disease. Although fatigue is recognized to significantly affect health-related quality of life, it remains underrecognised and empirically treated. In this paper, the prevalence of fatigue as measured by a validated visual analogue scale and the Parkinson's disease nonmotor symptoms scale (PDNMSS) was correlated with other motor and nonmotor comorbidities. In a cohort of patients from a range of disease stages, occurrence of fatigue correlated closely with more advanced Parkinson's disease, as well as with depression, anxiety, and sleep disorders, hinting at a common underlying basis.
Author Anne Martin
Fabrizio Stocchi
Heather M. Gage
Antonini
K. Ray Chaudhuri
Per Odin
P. Barone
P. Martinez-Martin
P. E. S. Schartau
Vinod Metta
Kartik Logishetty
T. K. Kaluarachchi
AuthorAffiliation 7 Department of Neurological Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy
2 University Hospital Lewisham, London SE13 6LH, UK
3 University of Surrey, Surrey GU2 7XH, UK
1 National Parkinson Foundation Centre of Excellence, King's College Hospital, King's College London, Denmark Hill Campus, 9th Floor, Ruskin Wing, > London SE5 9RS, UK
8 Department of Neurology, IRCCS San Raffaele, 00163 Rome, Italy
9 Department of Neurology, IRCCS San Camillo Venice and University of Padua, 35122 Padua, Italy
4 Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain
5 Department of Neurology, University Hospital, Lund University, Lund, Sweden
6 Department of Neurology, Central Hospital, Reinkenheide, Bremerhaven, Germany
AuthorAffiliation_xml – name: 3 University of Surrey, Surrey GU2 7XH, UK
– name: 2 University Hospital Lewisham, London SE13 6LH, UK
– name: 8 Department of Neurology, IRCCS San Raffaele, 00163 Rome, Italy
– name: 6 Department of Neurology, Central Hospital, Reinkenheide, Bremerhaven, Germany
– name: 7 Department of Neurological Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy
– name: 1 National Parkinson Foundation Centre of Excellence, King's College Hospital, King's College London, Denmark Hill Campus, 9th Floor, Ruskin Wing, > London SE5 9RS, UK
– name: 5 Department of Neurology, University Hospital, Lund University, Lund, Sweden
– name: 4 Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain
– name: 9 Department of Neurology, IRCCS San Camillo Venice and University of Padua, 35122 Padua, Italy
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Copyright Copyright © 2011 Antonio Strafella et al.
Copyright © 2011 Vinod Metta et al. 2011
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Snippet Fatigue is a common yet poorly understood and underresearched nonmotor symptom in Parkinson's disease. Although fatigue is recognized to significantly affect...
Fatigue is a common yet poorly understood and underresearched nonmotor symptom in Parkinson’s disease. Although fatigue is recognized to significantly affect...
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Title The Possible Clinical Predictors of Fatigue in Parkinson’s Disease: A Study of 135 Patients as Part of International Nonmotor Scale Validation Project
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