Human Lipoxygenase Pathway Gene Variation and Association with Markers of Subclinical Atherosclerosis in the Diabetes Heart Study

Aims. Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds. Methods. Families with two or more siblings with type 2 di...

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Bibliographic Details
Published in:	Mediators of Inflammation Vol. 2010; no. 2010; pp. 72 - 80
Main Authors:	Freedman, Barry I., Carr, J. Jeffrey, Hedrick, Catherine C., Rich, Stephen S., Burdon, Kathryn P., Liu, Yongmei, Register, Thomas C., Bowden, Donald W., Rudock, Megan E., Lehtinen, Allison B., Langefeld, Carl D.
Format:	Journal Article
Language:	English
Published:	Cairo, Egypt Hindawi Limiteds 01.01.2010 Hindawi Puplishing Corporation Hindawi Publishing Corporation John Wiley & Sons, Inc Wiley
Subjects:	Aged Animals Arachidonate 5-Lipoxygenase - genetics Arachidonate 5-Lipoxygenase - metabolism Atherosclerosis Atherosclerosis - genetics Atherosclerosis - pathology Atherosclerosis - physiopathology Biomarkers - metabolism Development and progression Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - physiopathology Female Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease Genetic Variation Genotype Health aspects Humans Isoenzymes - genetics Isoenzymes - metabolism Middle Aged Oxidases Phenotype Polymorphism, Single Nucleotide United States
ISSN:	0962-9351, 1466-1861, 1466-1861
Online Access:	Get full text
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