Calorie Restriction and Aging in Humans

Calorie restriction (CR), the reduction of dietary intake below energy requirements while maintaining optimal nutrition, is the only known nutritional intervention with the potential to attenuate aging. Evidence from observational, preclinical, and clinical trials suggests the ability to increase li...

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Veröffentlicht in:Annual review of nutrition Jg. 40; S. 105
Hauptverfasser: Flanagan, Emily W, Most, Jasper, Mey, Jacob T, Redman, Leanne M
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 23.09.2020
Schlagworte:
Aging - drug effects
Aging - genetics
Animals
Diet
Eating
Food Analysis
Humans
calorie restriction
intermittent fasting
CALERIE
aging
metabolic adaptation
ISSN:1545-4312, 1545-4312
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Zusammenfassung:Calorie restriction (CR), the reduction of dietary intake below energy requirements while maintaining optimal nutrition, is the only known nutritional intervention with the potential to attenuate aging. Evidence from observational, preclinical, and clinical trials suggests the ability to increase life span by 1-5 years with an improvement in health span and quality of life. CR moderates intrinsic processes of aging through cellular and metabolic adaptations and reducing risk for the development of many cardiometabolic diseases. Yet, implementation of CR may require unique considerations for the elderly and other specific populations. The objectives of this review are to summarize the evidence for CR to modify primary and secondary aging; present caveats for implementation in special populations; describe newer, alternative approaches that have comparative effectiveness and fewer deleterious effects; and provide thoughts on the future of this important field of study.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1545-4312
1545-4312
DOI:10.1146/annurev-nutr-122319-034601