Light-Responsive and Antibacterial Graphenic Materials as a Holistic Approach to Tissue Engineering

While the continuous development of advanced bioprinting technologies is under fervent study, enhancing the regenerative potential of hydrogel-based constructs using external stimuli for wound dressing has yet to be tackled. Fibroblasts play a significant role in wound healing and tissue implants at...

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Veröffentlicht in:	ACS Nanoscience Au Jg. 4; H. 4; S. 263 - 272
Hauptverfasser:	Ferreras, Andrea, Matesanz, Ana, Mendizabal, Jabier, Artola, Koldo, Nishina, Yuta, Acedo, Pablo, Jorcano, José L., Ruiz, Amalia, Reina, Giacomo, Martín, Cristina
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States American Chemical Society 21.08.2024 American Chemical Society (ACS)
Schlagworte:	Chemical technology TP1-1185 alginate graphene derivatives tissue engineering photothermal therapy 4D bioprinting
ISSN:	2694-2496, 2694-2496
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Abstract	While the continuous development of advanced bioprinting technologies is under fervent study, enhancing the regenerative potential of hydrogel-based constructs using external stimuli for wound dressing has yet to be tackled. Fibroblasts play a significant role in wound healing and tissue implants at different stages, including extracellular matrix production, collagen synthesis, and wound and tissue remodeling. This study explores the synergistic interplay between photothermal activity and nanomaterial-mediated cell proliferation. The use of different graphene-based materials (GBM) in the development of photoactive bioinks is investigated. In particular, we report the creation of a skin-inspired dressing for wound healing and regenerative medicine. Three distinct GBM, namely, graphene oxide (GO), reduced graphene oxide (rGO), and graphene platelets (GP), were rigorously characterized, and their photothermal capabilities were elucidated. Our investigations revealed that rGO exhibited the highest photothermal efficiency and antibacterial properties when irradiated, even at a concentration as low as 0.05 mg/mL, without compromising human fibroblast viability. Alginate-based bioinks alongside human fibroblasts were employed for the bioprinting with rGO. The scaffold did not affect the survival of fibroblasts for 3 days after bioprinting, as cell viability was not affected. Remarkably, the inclusion of rGO did not compromise the printability of the hydrogel, ensuring the successful fabrication of complex constructs. Furthermore, the presence of rGO in the final scaffold continued to provide the benefits of photothermal antimicrobial therapy without detrimentally affecting fibroblast growth. This outcome underscores the potential of rGO-enhanced hydrogels in tissue engineering and regenerative medicine applications. Our findings hold promise for developing game-changer strategies in 4D bioprinting to create smart and functional tissue constructs with high fibroblast proliferation and promising therapeutic capabilities in drug delivery and bactericidal skin-inspired dressings.
AbstractList	While the continuous development of advanced bioprinting technologies is under fervent study, enhancing the regenerative potential of hydrogel-based constructs using external stimuli for wound dressing has yet to be tackled. Fibroblasts play a significant role in wound healing and tissue implants at different stages, including extracellular matrix production, collagen synthesis, and wound and tissue remodeling. This study explores the synergistic interplay between photothermal activity and nanomaterial-mediated cell proliferation. The use of different graphene-based materials (GBM) in the development of photoactive bioinks is investigated. In particular, we report the creation of a skin-inspired dressing for wound healing and regenerative medicine. Three distinct GBM, namely, graphene oxide (GO), reduced graphene oxide (rGO), and graphene platelets (GP), were rigorously characterized, and their photothermal capabilities were elucidated. Our investigations revealed that rGO exhibited the highest photothermal efficiency and antibacterial properties when irradiated, even at a concentration as low as 0.05 mg/mL, without compromising human fibroblast viability. Alginate-based bioinks alongside human fibroblasts were employed for the bioprinting with rGO. The scaffold did not affect the survival of fibroblasts for 3 days after bioprinting, as cell viability was not affected. Remarkably, the inclusion of rGO did not compromise the printability of the hydrogel, ensuring the successful fabrication of complex constructs. Furthermore, the presence of rGO in the final scaffold continued to provide the benefits of photothermal antimicrobial therapy without detrimentally affecting fibroblast growth. This outcome underscores the potential of rGO-enhanced hydrogels in tissue engineering and regenerative medicine applications. Our findings hold promise for developing game-changer strategies in 4D bioprinting to create smart and functional tissue constructs with high fibroblast proliferation and promising therapeutic capabilities in drug delivery and bactericidal skin-inspired dressings.While the continuous development of advanced bioprinting technologies is under fervent study, enhancing the regenerative potential of hydrogel-based constructs using external stimuli for wound dressing has yet to be tackled. Fibroblasts play a significant role in wound healing and tissue implants at different stages, including extracellular matrix production, collagen synthesis, and wound and tissue remodeling. This study explores the synergistic interplay between photothermal activity and nanomaterial-mediated cell proliferation. The use of different graphene-based materials (GBM) in the development of photoactive bioinks is investigated. In particular, we report the creation of a skin-inspired dressing for wound healing and regenerative medicine. Three distinct GBM, namely, graphene oxide (GO), reduced graphene oxide (rGO), and graphene platelets (GP), were rigorously characterized, and their photothermal capabilities were elucidated. Our investigations revealed that rGO exhibited the highest photothermal efficiency and antibacterial properties when irradiated, even at a concentration as low as 0.05 mg/mL, without compromising human fibroblast viability. Alginate-based bioinks alongside human fibroblasts were employed for the bioprinting with rGO. The scaffold did not affect the survival of fibroblasts for 3 days after bioprinting, as cell viability was not affected. Remarkably, the inclusion of rGO did not compromise the printability of the hydrogel, ensuring the successful fabrication of complex constructs. Furthermore, the presence of rGO in the final scaffold continued to provide the benefits of photothermal antimicrobial therapy without detrimentally affecting fibroblast growth. This outcome underscores the potential of rGO-enhanced hydrogels in tissue engineering and regenerative medicine applications. Our findings hold promise for developing game-changer strategies in 4D bioprinting to create smart and functional tissue constructs with high fibroblast proliferation and promising therapeutic capabilities in drug delivery and bactericidal skin-inspired dressings. While the continuous development of advanced bioprinting technologies is under fervent study, enhancing the regenerative potential of hydrogel-based constructs using external stimuli for wound dressing has yet to be tackled. Fibroblasts play a significant role in wound healing and tissue implants at different stages, including extracellular matrix production, collagen synthesis, and wound and tissue remodeling. This study explores the synergistic interplay between photothermal activity and nanomaterial-mediated cell proliferation. The use of different graphene-based materials (GBM) in the development of photoactive bioinks is investigated. In particular, we report the creation of a skin-inspired dressing for wound healing and regenerative medicine. Three distinct GBM, namely, graphene oxide (GO), reduced graphene oxide (rGO), and graphene platelets (GP), were rigorously characterized, and their photothermal capabilities were elucidated. Our investigations revealed that rGO exhibited the highest photothermal efficiency and antibacterial properties when irradiated, even at a concentration as low as 0.05 mg/mL, without compromising human fibroblast viability. Alginate-based bioinks alongside human fibroblasts were employed for the bioprinting with rGO. The scaffold did not affect the survival of fibroblasts for 3 days after bioprinting, as cell viability was not affected. Remarkably, the inclusion of rGO did not compromise the printability of the hydrogel, ensuring the successful fabrication of complex constructs. Furthermore, the presence of rGO in the final scaffold continued to provide the benefits of photothermal antimicrobial therapy without detrimentally affecting fibroblast growth. This outcome underscores the potential of rGO-enhanced hydrogels in tissue engineering and regenerative medicine applications. Our findings hold promise for developing game-changer strategies in 4D bioprinting to create smart and functional tissue constructs with high fibroblast proliferation and promising therapeutic capabilities in drug delivery and bactericidal skin-inspired dressings.
Author	Artola, Koldo Jorcano, José L. Nishina, Yuta Acedo, Pablo Reina, Giacomo Ferreras, Andrea Matesanz, Ana Martín, Cristina Ruiz, Amalia Mendizabal, Jabier
AuthorAffiliation	Universidad Carlos III de Madrid Research Core for Interdisciplinary Sciences Empa Swiss Federal Laboratories for Materials Science and Technology Department of Bioengineering Instituto de Investigación Sanitaria Gregorio Marañón Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences Department of Electronic Technology Graduate School of Natural Science and Technology Domotek ingeniería prototipado y formación S.L Okayama University
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References	ref9/cit9 ref45/cit45 ref3/cit3 ref27/cit27 ref63/cit63 ref56/cit56 ref16/cit16 ref52/cit52 ref23/cit23 ref8/cit8 ref31/cit31 ref59/cit59 ref2/cit2 ref34/cit34 ref37/cit37 ref20/cit20 ref48/cit48 ref60/cit60 ref17/cit17 ref10/cit10 ref35/cit35 ref53/cit53 ref19/cit19 ref21/cit21 ref42/cit42 ref46/cit46 ref49/cit49 ref13/cit13 ref61/cit61 ref24/cit24 ref38/cit38 ref50/cit50 ref64/cit64 ref54/cit54 ref6/cit6 ref36/cit36 ref18/cit18 ref11/cit11 ref25/cit25 ref29/cit29 ref32/cit32 ref39/cit39 ref14/cit14 ref57/cit57 ref5/cit5 ref51/cit51 ref43/cit43 ref28/cit28 ref40/cit40 ref26/cit26 ref55/cit55 ref12/cit12 ref15/cit15 ref62/cit62 ref41/cit41 ref58/cit58 ref22/cit22 ref33/cit33 ref4/cit4 ref30/cit30 ref47/cit47 ref1/cit1 ref44/cit44 ref7/cit7
References_xml	– ident: ref36/cit36 doi: 10.1021/acsnano.8b04758 – ident: ref32/cit32 doi: 10.1016/j.jallcom.2022.164091 – ident: ref58/cit58 doi: 10.3390/ma14040858 – ident: ref9/cit9 doi: 10.1016/j.actbio.2018.05.010 – ident: ref24/cit24 doi: 10.1128/JCM.01421-08 – ident: ref48/cit48 doi: 10.1021/acsnano.6b02039 – ident: ref61/cit61 doi: 10.1002/admt.202201917 – ident: ref42/cit42 doi: 10.1016/j.jhazmat.2020.122380 – ident: ref11/cit11 doi: 10.3390/pharmaceutics14122596 – ident: ref63/cit63 doi: 10.1016/j.carbon.2022.05.036 – ident: ref26/cit26 doi: 10.3390/pharmaceutics14071365 – ident: ref40/cit40 doi: 10.1103/PhysRevLett.97.187401 – ident: ref16/cit16 doi: 10.1186/s12967-021-02752-2 – ident: ref43/cit43 doi: 10.1038/ncomms1067 – ident: ref25/cit25 doi: 10.1002/smll.202207229 – ident: ref10/cit10 doi: 10.1089/ten.tea.2020.0210 – ident: ref34/cit34 doi: 10.1016/j.smaim.2020.09.001 – ident: ref51/cit51 doi: 10.1021/am200428v – ident: ref31/cit31 doi: 10.1155/2012/751075 – ident: ref37/cit37 doi: 10.1038/srep17422 – ident: ref38/cit38 doi: 10.1088/1758-5090/8/3/035020 – ident: ref2/cit2 doi: 10.1088/1758-5090/9/1/015006 – ident: ref5/cit5 doi: 10.1016/j.heliyon.2023.e20475 – ident: ref64/cit64 doi: 10.3390/toxics9030062 – ident: ref14/cit14 doi: 10.1159/000484405 – ident: ref29/cit29 doi: 10.3390/ijms19124031 – ident: ref44/cit44 doi: 10.1021/acs.chemmater.6b04807 – ident: ref47/cit47 doi: 10.1021/acs.chemrev.3c00159 – ident: ref56/cit56 doi: 10.3390/polym14020354 – ident: ref28/cit28 doi: 10.1002/smll.202204044 – ident: ref35/cit35 doi: 10.1039/C9CC01205B – ident: ref20/cit20 doi: 10.1089/mdr.2018.0319 – ident: ref21/cit21 doi: 10.1080/09506608.2023.2193784 – ident: ref33/cit33 doi: 10.1038/s41467-019-12313-3 – ident: ref46/cit46 doi: 10.1021/acsanm.2c03409 – ident: ref57/cit57 doi: 10.1016/j.actbio.2014.06.034 – ident: ref53/cit53 – ident: ref1/cit1 doi: 10.18063/ijb.v9i1.638 – ident: ref6/cit6 doi: 10.1021/acs.chemrev.0c00084 – ident: ref50/cit50 doi: 10.1021/acsami.8b18304 – ident: ref3/cit3 doi: 10.3389/fbioe.2019.00164 – ident: ref18/cit18 doi: 10.1021/acsmaterialslett.2c01044 – ident: ref49/cit49 doi: 10.1021/acsami.0c17523 – ident: ref17/cit17 doi: 10.1016/j.msec.2021.112352 – ident: ref45/cit45 doi: 10.1039/C8NR00333E – ident: ref4/cit4 doi: 10.1016/j.bprint.2020.e00093 – ident: ref8/cit8 doi: 10.36922/ijb.2135 – ident: ref27/cit27 doi: 10.1088/2053-1583/ac4572 – ident: ref59/cit59 doi: 10.3390/polym14112229 – ident: ref13/cit13 doi: 10.1111/j.1524-475X.2009.00496.x – ident: ref23/cit23 doi: 10.1016/j.diagmicrobio.2006.05.009 – ident: ref7/cit7 doi: 10.1007/s42242-023-00245-3 – ident: ref39/cit39 doi: 10.1002/smll.201900147 – ident: ref62/cit62 doi: 10.1016/j.ijbiomac.2024.129372 – ident: ref12/cit12 doi: 10.3390/bioengineering8020027 – ident: ref30/cit30 doi: 10.1021/ar7002804 – ident: ref52/cit52 doi: 10.1021/acsnano.7b07734 – ident: ref15/cit15 doi: 10.1111/j.1365-2133.2007.07914.x – ident: ref22/cit22 doi: 10.1111/tid.13897 – ident: ref55/cit55 doi: 10.1038/s41598-017-17286-1 – ident: ref41/cit41 doi: 10.1038/srep40572 – ident: ref60/cit60 doi: 10.1016/j.matdes.2022.110551 – ident: ref19/cit19 doi: 10.1021/acsami.0c00710 – ident: ref54/cit54 doi: 10.3390/ijms17121976
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Title	Light-Responsive and Antibacterial Graphenic Materials as a Holistic Approach to Tissue Engineering
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