Pooling designs and nonadaptive group testing important tools for DNA sequencing.
Pooling designs have been widely used in various aspects of DNA sequencing. In biological applications, the well-studied mathematical problem called “group testing” shifts its focus to nonadaptive algorithms while the focus of traditional group testing is on sequential algorithms. Biological applica...
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| Sprache: | Englisch |
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New Jersey
World Scientific Publishing Co. Pte. Ltd
2006
World Scientific World Scientific Publishing Company WORLD SCIENTIFIC WSPC |
| Schriftenreihe: | Series on applied mathematics |
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| ISBN: | 9789812568229, 9789812773463, 9812773460, 9812568220 |
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| Abstract | Pooling designs have been widely used in various aspects of DNA sequencing. In biological applications, the well-studied mathematical problem called “group testing” shifts its focus to nonadaptive algorithms while the focus of traditional group testing is on sequential algorithms. Biological applications also bring forth new models not previously considered, such as the error-tolerant model, the complex model, and the inhibitor model. This book is the first attempt to collect all the significant research on pooling designs in one convenient place. |
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| AbstractList | Pooling designs have been widely used in various aspects of DNA sequencing. In biological applications, the well-studied mathematical problem called “group testing” shifts its focus to nonadaptive algorithms while the focus of traditional group testing is on sequential algorithms. Biological applications also bring forth new models not previously considered, such as the error-tolerant model, the complex model, and the inhibitor model. This book is the first attempt to collect all the significant research on pooling designs in one convenient place. Pooling designs have been widely used in various aspects of DNA sequencing. In biological applications, the well-studied mathematical problem called "group testing" shifts its focus to nonadaptive algorithms while the focus of traditional group testing is on sequential algorithms. Biological applications also bring forth new models not previously considered, such as the error-tolerant model, the complex model, and the inhibitor model. This book is the first attempt to collect all the significant research on pooling designs in one convenient place.The coverage includes many real biological applications such as clone library screening, contig sequencing, exon boundary finding and protein-protein interaction detecting and introduces the mathematics behind it.Sample Chapter(s)Chapter 1: Introduction (852 KB)Contents:Basic Theory on Separating MatricesDeterministic DesignsDeterministic Designs from Partial OrdersRandom Pooling Designs and Probabilistic AnalysisPooling Designs on ComplexesContig SequencingThe Inhibitor ModelHyperplane DesignsNon-Unique Probe SelectionReadership: Graduate students and researchers in computational biology and discrete mathematics. Pooling designs have been widely used in various aspects of DNA sequencing. In biological applications, the well-studied mathematical problem called "group testing" shifts its focus to nonadaptive algorithms while the focus of traditional group testing is on sequential algorithms. Biological applications also bring forth new models not previously considered, such as the error-tolerant model, the complex model, and the inhibitor model. This book is the first attempt to collect all the significant research on pooling designs in one convenient place. The coverage includes many real biological applications such as clone library screening, contig sequencing, exon boundary finding and protein-protein interaction detecting and introduces the mathematics behind it. |
| Author | Du, Dingzhu Hwang, Frank K |
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| Keywords | Clone Library Screening Disjunct Matrix Pooling Designs Group Testing DNA Sequencing Physical Mapping |
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| Notes | Includes bibliographical references and index |
| PageCount | 249 |
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| Snippet | Pooling designs have been widely used in various aspects of DNA sequencing. In biological applications, the well-studied mathematical problem called “group... Pooling designs have been widely used in various aspects of DNA sequencing. In biological applications, the well-studied mathematical problem called "group... |
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| SubjectTerms | Bioinformatics and Computational Biology BioMathematics Biostatistics Combinatorial group theory Molecular biology Molecular biology -- Mathematics Nucleotide sequence Nucleotide sequence -- Mathematics SCIENCE |
| SubjectTermsDisplay | Combinatorial group theory Molecular biology Nucleotide sequence |
| Subtitle | important tools for DNA sequencing. |
| TableOfContents | Pooling designs and nonadaptive group testing : important tools for DNA sequencing -- Preface -- Contents -- 1. Introduction -- 2. Basic Theory on Separating Matrices -- 3. Deterministic Designs -- 4. Deterministic Designs from Partial Orders -- 5. Random Pooling Designs and Probabilistic Analysis -- 6. Pooling Designs on Complexes -- 7. Contig Sequencing -- 8. The Inhibitor Model -- 9. Hyperplane Designs -- 10. Non-unique Probe Selection -- Index -- Back Cover |
| Title | Pooling designs and nonadaptive group testing |
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