Gene Expression of IGF1, IGF1R, and IGFBP3 in Epiretinal Membranes of Patients with Proliferative Diabetic Retinopathy: Preliminary Study

The molecular mechanism formation of secondary epiretinal membranes (ERMs) after proliferative diabetic retinopathy (PDR) or primary idiopathic ERMs is still poorly understood. Therefore, the present study focused on the assessment of IGF1, IGF1R, and IGFBP3 mRNA levels in ERMs and PBMCs from patien...

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Veröffentlicht in:Mediators of Inflammation Jg. 2013; H. 2013; S. 662 - 668
Hauptverfasser: Kimsa, Malgorzata W., Romaniuk, Dorota, Strzalka-Mrozik, Barbara, Kimsa, Magdalena C., Kabiesz, Adam, Romaniuk, Wanda, Mazurek, Urszula
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Cairo, Egypt Hindawi Limiteds 01.01.2013
Hindawi Puplishing Corporation
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Wiley
Schlagworte:
Aged
Aged, 80 and over
Clinical Study
Development and progression
Diabetic nephropathies
Diabetic Retinopathy - etiology
Diabetic Retinopathy - metabolism
Diabetic Retinopathy - surgery
Epiretinal Membrane - metabolism
Female
Genetic aspects
Growth factors
Humans
Insulin-Like Growth Factor Binding Protein 3 - genetics
Insulin-Like Growth Factor Binding Protein 3 - physiology
Insulin-Like Growth Factor I - genetics
Insulin-Like Growth Factor I - physiology
Leukocytes, Mononuclear - metabolism
Male
Messenger RNA
Properties
Real-Time Polymerase Chain Reaction
Receptor, IGF Type 1 - genetics
Receptor, IGF Type 1 - physiology
Reverse Transcriptase Polymerase Chain Reaction
Vitreoretinopathy, Proliferative - etiology
ISSN:0962-9351, 1466-1861, 1466-1861
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Abstract The molecular mechanism formation of secondary epiretinal membranes (ERMs) after proliferative diabetic retinopathy (PDR) or primary idiopathic ERMs is still poorly understood. Therefore, the present study focused on the assessment of IGF1, IGF1R, and IGFBP3 mRNA levels in ERMs and PBMCs from patients with PDR. The examined group comprised 6 patients with secondary ERMs after PDR and the control group consisted of 11 patients with idiopathic ERMs. Quantification of IGF1, IGF1R, and IGFBP3 mRNAs was performed by real-time QRT-PCR technique. In ERMs, IGF1 and IGF1R mRNA levels were significantly higher in patients with diabetes compared to control subjects. In PBMCs, there were no statistically significant differences of IGF1, IGF1R, and IGFBP3 expression between diabetic and nondiabetic patients. In conclusion, our study indicated IGF1 and IGF1R differential expression in ERMs, but not in PBMCs, of diabetic and nondiabetic patients, suggesting that these factors can be involved in the pathogenesis or progression of proliferative vitreoretinal disorders. This trial is registered with NCT00841334.
AbstractList The molecular mechanism formation of secondary epiretinal membranes (ERMs) after proliferative diabetic retinopathy (PDR) or primary idiopathic ERMs is still poorly understood. Therefore, the present study focused on the assessment of IGF1, IGF1R, and IGFBP3 mRNA levels in ERMs and PBMCs from patients with PDR. The examined group comprised 6 patients with secondary ERMs after PDR and the control group consisted of 11 patients with idiopathic ERMs. Quantification of IGF1, IGF1R, and IGFBP3 mRNAs was performed by real-time QRT-PCR technique. In ERMs, IGF1 and IGF1R mRNA levels were significantly higher in patients with diabetes compared to control subjects. In PBMCs, there were no statistically significant differences of IGF1, IGF1R, and IGFBP3 expression between diabetic and nondiabetic patients. In conclusion, our study indicated IGF1 and IGF1R differential expression in ERMs, but not in PBMCs, of diabetic and nondiabetic patients, suggesting that these factors can be involved in the pathogenesis or progression of proliferative vitreoretinal disorders. This trial is registered with NCT00841334.
The molecular mechanism formation of secondary epiretinal membranes (ERMs) after proliferative diabetic retinopathy (PDR) or primary idiopathic ERMs is still poorly understood. Therefore, the present study focused on the assessment of IGF1, IGF1R, and IGFBP3 mRNA levels in ERMs and PBMCs from patients with PDR. The examined group comprised 6 patients with secondary ERMs after PDR and the control group consisted of 11 patients with idiopathic ERMs. Quantification of IGF1, IGF1R, and IGFBP3 mRNAs was performed by real-time QRT-PCR technique. In ERMs, IGF1 and IGF1R mRNA levels were significantly higher in patients with diabetes compared to control subjects. In PBMCs, there were no statistically significant differences of IGF1, IGF1R, and IGFBP3 expression between diabetic and nondiabetic patients. In conclusion, our study indicated IGF1 and IGF1R differential expression in ERMs, but not in PBMCs, of diabetic and nondiabetic patients, suggesting that these factors can be involved in the pathogenesis or progression of proliferative vitreoretinal disorders. This trial is registered with NCT00841334.The molecular mechanism formation of secondary epiretinal membranes (ERMs) after proliferative diabetic retinopathy (PDR) or primary idiopathic ERMs is still poorly understood. Therefore, the present study focused on the assessment of IGF1, IGF1R, and IGFBP3 mRNA levels in ERMs and PBMCs from patients with PDR. The examined group comprised 6 patients with secondary ERMs after PDR and the control group consisted of 11 patients with idiopathic ERMs. Quantification of IGF1, IGF1R, and IGFBP3 mRNAs was performed by real-time QRT-PCR technique. In ERMs, IGF1 and IGF1R mRNA levels were significantly higher in patients with diabetes compared to control subjects. In PBMCs, there were no statistically significant differences of IGF1, IGF1R, and IGFBP3 expression between diabetic and nondiabetic patients. In conclusion, our study indicated IGF1 and IGF1R differential expression in ERMs, but not in PBMCs, of diabetic and nondiabetic patients, suggesting that these factors can be involved in the pathogenesis or progression of proliferative vitreoretinal disorders. This trial is registered with NCT00841334.
Audience Academic
Author Kimsa, Magdalena C.
Romaniuk, Wanda
Kabiesz, Adam
Mazurek, Urszula
Kimsa, Malgorzata W.
Strzalka-Mrozik, Barbara
Romaniuk, Dorota
AuthorAffiliation 2 Department of Molecular Biology, Medical University of Silesia, Narcyzów Street 1, 41-200 Sosnowiec, Poland
1 Clinical Department of Ophthalmology, Medical University of Silesia, Ceglana Street 35, 40-952 Katowice, Poland
AuthorAffiliation_xml – name: 1 Clinical Department of Ophthalmology, Medical University of Silesia, Ceglana Street 35, 40-952 Katowice, Poland
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ContentType Journal Article
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Kabiesz, Adam
Mazurek, Urszula
Strzalka-Mrozik, Barbara
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Copyright Copyright © 2013 Dorota Romaniuk et al.
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Snippet The molecular mechanism formation of secondary epiretinal membranes (ERMs) after proliferative diabetic retinopathy (PDR) or primary idiopathic ERMs is still...
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StartPage 662
SubjectTerms Aged
Aged, 80 and over
Clinical Study
Development and progression
Diabetic nephropathies
Diabetic Retinopathy - etiology
Diabetic Retinopathy - metabolism
Diabetic Retinopathy - surgery
Epiretinal Membrane - metabolism
Female
Genetic aspects
Growth factors
Humans
Insulin-Like Growth Factor Binding Protein 3 - genetics
Insulin-Like Growth Factor Binding Protein 3 - physiology
Insulin-Like Growth Factor I - genetics
Insulin-Like Growth Factor I - physiology
Leukocytes, Mononuclear - metabolism
Male
Messenger RNA
Properties
Real-Time Polymerase Chain Reaction
Receptor, IGF Type 1 - genetics
Receptor, IGF Type 1 - physiology
Reverse Transcriptase Polymerase Chain Reaction
Vitreoretinopathy, Proliferative - etiology
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Title Gene Expression of IGF1, IGF1R, and IGFBP3 in Epiretinal Membranes of Patients with Proliferative Diabetic Retinopathy: Preliminary Study
URI https://www.airitilibrary.com/Article/Detail/P20160527003-201312-201703020022-201703020022-662-668
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Volume 2013
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