Sociodemographic and Perinatal Predictors of Early Pregnancy Per- and Polyfluoroalkyl Substance (PFAS) Concentrations

Per- and polyfluoroalkyl substances (PFASs), used in food packaging and stain-resistant coatings, are suspected developmental toxicants that are ubiquitous and persistent in the environment. We measured plasma PFAS concentrations during early pregnancy (median = 9.7 weeks gestation) among 1645 women...

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Vydáno v:Environmental science & technology Ročník 49; číslo 19; s. 11849
Hlavní autoři: Sagiv, Sharon K, Rifas-Shiman, Sheryl L, Webster, Thomas F, Mora, Ana Maria, Harris, Maria H, Calafat, Antonia M, Ye, Xiaoyun, Gillman, Matthew W, Oken, Emily
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 06.10.2015
Témata:
Adult
Alkanesulfonic Acids - blood
Boston
Caprylates - blood
Cohort Studies
Environmental Pollutants - blood
Female
Fluorocarbons - blood
Glomerular Filtration Barrier
Humans
Linear Models
Maternal Age
Parity
Pregnancy
Pregnancy Trimester, First - blood
Pregnancy Trimester, Second - blood
Socioeconomic Factors
Sulfonic Acids - blood
Young Adult
ISSN:1520-5851, 1520-5851
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Popis
Shrnutí:Per- and polyfluoroalkyl substances (PFASs), used in food packaging and stain-resistant coatings, are suspected developmental toxicants that are ubiquitous and persistent in the environment. We measured plasma PFAS concentrations during early pregnancy (median = 9.7 weeks gestation) among 1645 women in the Boston-area Project Viva cohort, recruited during 1999-2002. We used multivariable linear regression to estimate associations of sociodemographic and perinatal predictors, including measures of pregnancy physiology (albumin, glomerular filtration rate (GFR)), with log-transformed plasma PFAS concentrations. Geometric mean concentrations for the four main PFASs, perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), perfluorohexanesulfonate (PFHxS) and perfluorononanoate (PFNA) were 25.4, 5.7, 2.5, and 0.6 ng/mL, respectively, comparable with general U.S. population concentrations during those years. Higher early pregnancy PFAS concentrations were associated with younger age (except PFNA), less educational attainment, nulliparity, no history of breastfeeding and higher prepregnancy body mass index in adjusted models. In addition, lower GFR was associated with 3-4% higher PFAS concentrations and higher albumin was associated with 4-6% higher PFAS concentrations. Our results show associations consistent (parity and breastfeeding) and less consistent (age and education) with previous studies. We also report associations with GFR and albumin, which were strongly related to PFAS concentrations and thus could confound estimates of PFAS-outcome associations in epidemiologic studies.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1520-5851
1520-5851
DOI:10.1021/acs.est.5b02489