Liposarcoma: Molecular Genetics and Therapeutics

Sarcomas are a group of heterogeneous tumours with varying genetic basis. Cytogenetic abnormalities range from distinct genomic rearrangements such as pathognomonic translocation events and common chromosomal amplification or loss, to more complex rearrangements involving multiple chromosomes. The d...

Full description

Saved in:
Bibliographic Details
Published in:Sarcoma Vol. 2011; no. 2011; pp. 256 - 268
Main Authors: Conyers, Rachel, Young, Sophie, Thomas, David M.
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Limiteds 2011
Hindawi Puplishing Corporation
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Subjects:
Care and treatment
Development and progression
Genetic aspects
Liposarcoma
Molecular genetics
Review
Australia
ISSN:1357-714X, 1369-1643, 1369-1643
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sarcomas are a group of heterogeneous tumours with varying genetic basis. Cytogenetic abnormalities range from distinct genomic rearrangements such as pathognomonic translocation events and common chromosomal amplification or loss, to more complex rearrangements involving multiple chromosomes. The different subtypes of liposarcoma are spread across this spectrum and constitute an interesting tumour type for molecular review. This paper will outline molecular pathogenesis of the three main subtypes of liposarcoma: well-differentiated/dedifferentiated, myxoid/round cell, and pleomorphic liposarcoma. Both the molecular basis and future avenues for therapeutic intervention will be discussed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Academic Editor: Stephen Lessnick
ISSN:1357-714X
1369-1643
1369-1643
DOI:10.1155/2011/483154