Liposarcoma: Molecular Genetics and Therapeutics

Sarcomas are a group of heterogeneous tumours with varying genetic basis. Cytogenetic abnormalities range from distinct genomic rearrangements such as pathognomonic translocation events and common chromosomal amplification or loss, to more complex rearrangements involving multiple chromosomes. The d...

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Vydáno v:Sarcoma Ročník 2011; číslo 2011; s. 256 - 268
Hlavní autoři: Conyers, Rachel, Young, Sophie, Thomas, David M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Cairo, Egypt Hindawi Limiteds 2011
Hindawi Puplishing Corporation
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Témata:
Care and treatment
Development and progression
Genetic aspects
Liposarcoma
Molecular genetics
Review
Australia
ISSN:1357-714X, 1369-1643, 1369-1643
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Popis
Shrnutí:Sarcomas are a group of heterogeneous tumours with varying genetic basis. Cytogenetic abnormalities range from distinct genomic rearrangements such as pathognomonic translocation events and common chromosomal amplification or loss, to more complex rearrangements involving multiple chromosomes. The different subtypes of liposarcoma are spread across this spectrum and constitute an interesting tumour type for molecular review. This paper will outline molecular pathogenesis of the three main subtypes of liposarcoma: well-differentiated/dedifferentiated, myxoid/round cell, and pleomorphic liposarcoma. Both the molecular basis and future avenues for therapeutic intervention will be discussed.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Academic Editor: Stephen Lessnick
ISSN:1357-714X
1369-1643
1369-1643
DOI:10.1155/2011/483154