In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection

The profile of PC945, a novel triazole antifungal designed for administration via inhalation, was assessed in a range of and studies. PC945 was characterized as a potent, tightly binding inhibitor of sterol 14α-demethylase (CYP51A and CYP51B) activity (50% inhibitory concentrations [IC s], 0.23 μM a...

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Vydané v:	Antimicrobial agents and chemotherapy Ročník 61; číslo 5
Hlavní autori:	Colley, Thomas, Alanio, Alexandre, Kelly, Steven L, Sehra, Gurpreet, Kizawa, Yasuo, Warrilow, Andrew G S, Parker, Josie E, Kelly, Diane E, Kimura, Genki, Anderson-Dring, Lauren, Nakaoki, Takahiro, Sunose, Mihiro, Onions, Stuart, Crepin, Damien, Lagasse, Franz, Crittall, Matthew, Shannon, Jonathan, Cooke, Michael, Bretagne, Stéphane, King-Underwood, John, Murray, John, Ito, Kazuhiro, Strong, Pete, Rapeport, Garth
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.05.2017
Predmet:	Animals Antifungal Agents - pharmacology Aspergillosis - drug therapy Aspergillosis - microbiology Aspergillus fumigatus - drug effects Aspergillus fumigatus - isolation & purification Benzamides - pharmacology Cells, Cultured Cytochrome P-450 Enzyme System Fungal Proteins - antagonists & inhibitors Humans Itraconazole - pharmacology Mice Microbial Sensitivity Tests Triazoles - pharmacology Voriconazole - pharmacology inhalation Aspergillus fumigatus CYP51 azole azole resistant long acting
ISSN:	1098-6596
On-line prístup:	Zistit podrobnosti o prístupe
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