Mass spectrometry in sports drug testing characterization of prohibited substances and doping control analytical assays
Enables you to detect, identify, and characterize hundreds of drugs that may be used by athletes Mass spectrometry has become essential to sports drug testing. This book examines both the principles of sports drug testing and the use of mass spectrometry techniques and mass spectral data to detect,...
Uložené v:
| Hlavný autor: | |
|---|---|
| Médium: | E-kniha Kniha |
| Jazyk: | English |
| Vydavateľské údaje: |
Hoboken, N.J
WILEY
2010
Wiley John Wiley & Sons, Incorporated Wiley-Blackwell |
| Vydanie: | 1 |
| Edícia: | Wiley-Interscience series in mass spectrometry |
| Predmet: | |
| ISBN: | 9780470413272, 9780470626627, 0470626623, 0470413271, 0470626631, 9780470626634 |
| On-line prístup: | Získať plný text |
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- 3.5.2 Benzoic Acid-Derived Loop Diuretics -- 3.5.3 Potassium-Sparing Diuretics -- 3.6 β2-AGONISTS -- 3.7 β-RECEPTOR BLOCKING AGENTS -- 3.8 CALCIUM-CHANNEL MODULATORS (RYCALS) -- 3.9 CARBOHYDRATE-BASED AGENTS -- 3.9.1 Mannitol -- 3.9.2 Glycerol -- 3.9.3 Hydroxyethyl Starch and Dextran -- REFERENCES -- 4: Structure Characterization of Low Molecular Weight Target Analytes: Electrospray Ionization -- 4.1 STIMULANTS -- 4.2 NARCOTICS -- 4.3 ANABOLIC ANDROGENIC STEROIDS -- 4.3.1 α,β-Saturated 3-Keto-Steroids -- 4.3.2 3-Keto-4-ene and 3-Keto-1-ene Steroids -- 4.3.3 3-Keto-1,4-diene Steroids -- 4.3.4 3-Keto-4,6-diene Steroids -- 4.3.5 3-Keto-4,9-diene Steroids -- 4.3.6 3-Keto-4,9,11-triene Steroids -- 4.3.7 Stanozolol -- 4.4 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMs) -- 4.4.1 Arylpropionamide-Derived SARMs -- 4.4.2 Hydroxybicyclic Hydantoin-Derived SARMs -- 4.4.3 2-Quinolinone-Derived SARMs -- 4.4.4 Tetrahydroquinoline-Derived SARMs -- 4.5 DIURETICS -- 4.5.1 Thiazide-Derived Drugs -- 4.5.2 Benzoic Acid-Derived Loop Diuretics -- 4.5.3 Potassium-Sparing Diuretics -- 4.6 β-AGONISTS -- 4.7 CALCIUM-CHANNEL MODULATORS (RYCALS) -- 4.8 PEROXISOME-PROLIFERATOR ACTIVATED RECEPTOR-δ (PPARδ) AND ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE (AMPK) AGONISTS -- 4.9 HYPOXIA-INDUCIBLE FACTOR (HIF)-STABILIZERS AND SIRTUIN ACTIVATORS -- 4.9.1 HIF-Stabilizers -- 4.9.2 Sirtuin Activators -- 4.10 β-RECEPTOR BLOCKING AGENTS -- 4.11 GLUCURONIC ACID AND SULFATE CONJUGATES OF TARGET ANALYTES -- REFERENCES -- 5: Structure Characterization of High Molecular Weight Target Analytes: Electrospray Ionization -- 5.1 HUMAN CHORIONIC GONADOTROPHIN (HCG) -- 5.2 ERYTHROPOIETINS (EPO) -- 5.3 SYNACTHEN -- 5.4 INSULINS -- 5.5 HEMOGLOBIN-BASED OXYGEN CARRIERS (HBOCs) -- 5.6 HUMAN GROWTH HORMONE (HGH) -- 5.7 SERMORELIN (GEREF) -- 5.8 INSULIN-LIKE GROWTH FACTOR-1 (IGF-1)
- 5.9 GONADORELIN (LHRH) -- REFERENCES -- 6: Modern Mass Spectrometry-Based Analytical Assays -- 6.1 GC-MS AND ISOTOPE RATIO MASS SPECTROMETRY -- 6.1.1 Stimulants/Narcotics -- 6.1.2 Anabolic Androgenic Steroids -- 6.1.3 Diuretics -- 6.1.4 β2-Agonists and β-Receptor Blocking Agents -- 6.1.5 Carbohydrate-Based Agents -- 6.2 LC-MS/MS -- 6.2.1 Stimulants/narcotics/β2-Agonists/β-Receptor Blocking Agents -- 6.2.2 Anabolic Androgenic Steroids/Corticosteroids/Hormone Antagonists and Modulators -- 6.2.3 Masking Agents (Including Diuretics) -- 6.2.4 Peptide Hormones < -- 10kDa Including Insulins, Synacthen, Gonadorelin, IGF-1 -- 6.2.5 Hemoglobin-Based Oxygen Carriers -- 6.2.6 Human Chorionic Gonadotrophin (hCG) -- REFERENCES -- 7: Limitations and Perspectives of Mass Spectrometry-Based Procedures in Doping Control Analysis -- 7.1 RECOMBINANT BIOMOLECULES -- 7.1.1 Erythropoietin -- 7.1.2 Human Growth Hormone -- 7.1.3 Human Insulin and IGF-1 -- 7.2 UNKNOWN COMPOUNDS -- 7.3 PROFILING OF URINE AND/OR BLOOD -- 7.4 ALTERNATIVE SPECIMENS -- REFERENCES -- INDEX
- MASS SPECTROMETRY IN SPORTS DRUG TESTING: Characterization of Prohibited Substances and Doping Control Analytical Assays -- CONTENTS -- PREFACE -- ACKNOWLEDGMENTS -- 1: History of Sports Drug Testing -- 1.1 HISTORICAL ATTEMPTS OF ARTIFICIAL PERFORMANCE ENHANCEMENT -- 1.2 BACKGROUND AND RATIONALE OF DOPING CONTROLS -- 1.2.1 Cheating -- 1.2.2 Health Issues -- 1.2.3 Ethical Issues -- 1.3 EARLY DETECTION METHODS: POSSIBILITIES AND LIMITATIONS OF ASSAYS WITHOUT MASS SPECTROMETRY -- 1.3.1 First Applications Using Chemical and Biological Approaches in Horse Doping Control -- 1.3.2 First Applications Using Chemical Approaches in Human Doping Control -- 1.4 INTRODUCTION OF MASS SPECTROMETRY TO DOPING CONTROL ANALYSIS -- 1.4.1 First Approaches and Adverse Analytical Findings -- 1.4.2 Progression of Analytical Methods -- REFERENCES -- 2: Mass Spectrometry and the List of Prohibited Substances and Methods of Doping -- 2.1 CRITERIA FOR THE MASS SPECTROMETRIC IDENTIFICATION OF PROHIBITED COMPOUNDS -- 2.1.1 Low Molecular Weight Analytes -- 2.1.2 High Molecular Weight Analytes -- 2.2 MODERN MASS SPECTROMETERS IN DOPING CONTROLS: ADVANTAGES AND DISADVANTAGES OF AVAILABLE TECHNIQUES -- 2.2.1 Ionization Techniques in Routine Doping Controls -- 2.2.2 Mass Analyzers in Routine Doping Controls -- REFERENCES -- 3: Structure Characterization of Low Molecular Weight Target Analytes-Electron Ionization -- 3.1 STIMULANTS -- 3.2 NARCOTICS -- 3.3 ANABOLIC ANDROGENIC STEROIDS -- 3.3.1 Unsaturated 3-Keto-Steroids -- 3.3.2 α,β-Saturated Keto-Steroids -- 3.3.3 3-Keto-1,4-Diene, 3-Keto-4,6-Diene, and 3-Keto-4,9(11)-Diene Steroids -- 3.3.4 Steroid Derivatization -- 3.4 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMs) -- 3.4.1 2-Quinolinone-Based SARMs -- 3.4.2 Hydroxybicyclic Hydantoin-Derived SARMs -- 3.5 DIURETICS -- 3.5.1 Thiazide-Derived Drugs