Modeling supercoiled DNA interacting with an anchored cluster of proteins: towards a quantitative estimation of chromosomal DNA supercoiling

We investigate the measurement of DNA supercoiling density ($σ$) along chromosomes using interaction frequencies between DNA and DNA-anchored clusters of proteins. Specifically, we show how the physics of DNA supercoiling leads, in bacteria, to the quantitative modeling of binding properties of ParB...

Full description

Bibliographic Details

Published in:	PLoS computational biology Vol. 56; no. 6
Main Authors:	Walter, Jean-Charles, Lepage, Thibaut, Dorignac, Jérôme, Geniet, Frédéric, Parmeggiani, Andrea, Palmeri, John, Bouet, Jean-Yves, Junier, Ivan
Format:	Journal Article
Language:	English
Published:	PLOS 31.01.2020
Subjects:	Biological Physics Physics FOS: Biological sciences FOS: Physical sciences Biological Physics (physics.bio-ph) Biomolecules (q-bio.BM)
ISSN:	1553-734X, 1553-7358
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!