Modeling supercoiled DNA interacting with an anchored cluster of proteins: towards a quantitative estimation of chromosomal DNA supercoiling

We investigate the measurement of DNA supercoiling density ($σ$) along chromosomes using interaction frequencies between DNA and DNA-anchored clusters of proteins. Specifically, we show how the physics of DNA supercoiling leads, in bacteria, to the quantitative modeling of binding properties of ParB...

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Vydané v:	PLoS computational biology Ročník 56; číslo 6
Hlavní autori:	Walter, Jean-Charles, Lepage, Thibaut, Dorignac, Jérôme, Geniet, Frédéric, Parmeggiani, Andrea, Palmeri, John, Bouet, Jean-Yves, Junier, Ivan
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	PLOS 31.01.2020
Predmet:	Biological Physics Physics FOS: Biological sciences FOS: Physical sciences Biological Physics (physics.bio-ph) Biomolecules (q-bio.BM)
ISSN:	1553-734X, 1553-7358
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