Accurate Identification of Deamidation and Citrullination from Global Shotgun Proteomics Data Using a Dual-Search Delta Score Strategy

Proteins with deamidated/citrullinated amino acids play critical roles in the pathogenesis of many human diseases; however, identifying these modifications in complex biological samples has been an ongoing challenge. Herein we present a method to accurately identify these modifications from shotgun...

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Veröffentlicht in:	Journal of proteome research Jg. 19; H. 4; S. 1863
Hauptverfasser:	Wang, Xi, Swensen, Adam C, Zhang, Tong, Piehowski, Paul D, Gaffrey, Matthew J, Monroe, Matthew E, Zhu, Ying, Dong, Hailiang, Qian, Wei-Jun
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 03.04.2020
Schlagworte:	deamidation dual search Delta Score citrullination shotgun proteomics
ISSN:	1535-3907, 1535-3907
Online-Zugang:	Weitere Angaben
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