Vascular Density in Retina and Choriocapillaris as Measured by Optical Coherence Tomography Angiography

To measure the density of the superficial retinal small vessel network (SRSVN), superficial retinal capillary network (SRCN), deep retinal capillary network (DRCN), and choriocapillaris and the size of the foveal avascular zone (FAZ) in the superficial retinal layer in normal eyes. Prospective obser...

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Vydáno v:American journal of ophthalmology Ročník 168; s. 95 - 109
Hlavní autoři: Wang, Qian, Chan, Szyyann, Yang, Jing Yan, You, Bing, Wang, Ya Xing, Jonas, Jost B., Wei, Wen Bin
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 01.08.2016
Elsevier Limited
Témata:
Adult
Asian Continental Ancestry Group
Capillaries - anatomy & histology
Choroid - blood supply
Cross-Sectional Studies
Diabetes
Diabetic retinopathy
Female
Fluorescein Angiography
Fovea Centralis - blood supply
Humans
Male
Medical imaging
Middle Aged
Ophthalmology
Optics
Prospective Studies
Quality
Regression Analysis
Retina
Retina - anatomy & histology
Retinal Vessels - anatomy & histology
Tomography
Tomography, Optical Coherence - methods
Young Adult
Beijing China
California
United States > US
China
Optical coherence tomography angiography
Angiography
Angio OCT
ISSN:0002-9394, 1879-1891, 1879-1891
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Popis
Shrnutí:To measure the density of the superficial retinal small vessel network (SRSVN), superficial retinal capillary network (SRCN), deep retinal capillary network (DRCN), and choriocapillaris and the size of the foveal avascular zone (FAZ) in the superficial retinal layer in normal eyes. Prospective observational cross-sectional study. In healthy Chinese volunteers, the retinal and choroidal vasculature was visualized by split-spectrum amplitude decorrelation angiography–associated optical coherence tomography (RTVueXR Avanti device; Optovue Inc, Fremont, California, USA). Among 105 healthy participants (age: 35.9 ± 13.8 years) mean FAZ measured 0.35 ± 0.12 mm2, and mean density of SRSVN, SRCN, DRCN, and choriocapillaris was 8.54% ± 0.92%, 31.8% ± 2.6%, 45.8% ± 3.3%, 44.4% ± 3.3%, and 44.5% ± 2.7%, respectively. In multivariate analysis, higher SRSVN density was associated with younger age (P = .001; standardized regression coefficient β: −0.28), male sex (P = .008; β: −0.23), lower SRCN density (P < .001; β: −0.40), and larger mean choriocapillaris vessel diameter (P = .001; β: 0.30). Higher SRCN density was correlated with male sex (P = .007; β: −0.19), lower SRSVN density (P < .001; β: −0.44), and higher density of the radial peripapillary capillary density (P = .004; β: 0.20). Higher DRCN density was correlated with younger age (P < .001; β: −0.31), female sex (P = .002; β: 0.22), higher SRCN density (P < .001; β: 0.38), and higher choriocapillaris density (P < .001; β: 0.39). Higher choriocapillaris network density in the central region was associated with higher DRCN density (P < .001; β: 0.43) and lower radial peripapillary capillary density (P = .005; β: −0.26). All retinal vascular parameters were not significantly correlated with axial length or subfoveal choroidal thickness. The density of the macular vascular networks decreases with older age and is independent of axial length and subfoveal choroidal thickness in healthy individuals.
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ISSN:0002-9394
1879-1891
1879-1891
DOI:10.1016/j.ajo.2016.05.005