Translational Control during Cellular Senescence

Senescence is a state of long-term cell cycle arrest that arises in cells that have incurred sublethal damage. While senescent cells no longer replicate, they remain metabolically active and further develop unique and stable phenotypes that are not present in proliferating cells. On one hand, senesc...

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Vydáno v:	Molecular and cellular biology Ročník 41; číslo 2
Hlavní autoři:	Payea, Matthew J., Anerillas, Carlos, Tharakan, Ravi, Gorospe, Myriam
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Taylor & Francis 01.02.2021 American Society for Microbiology
Témata:	aging beta-Galactosidase - genetics beta-Galactosidase - metabolism biogenesis Biomarkers - metabolism cell cycle checkpoints cell senescence Cell Size Cells, Cultured cellular senescence Cellular Senescence - genetics Chemokines - genetics Chemokines - metabolism Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism DNA Damage Humans Mechanistic Target of Rapamycin Complex 1 - genetics Mechanistic Target of Rapamycin Complex 1 - metabolism Minireview Phenotype Protein Biosynthesis ribosomes RNA, Ribosomal - genetics RNA, Ribosomal - metabolism stress response translation elongation translation initiation translational control Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism translation initiation cellular senescence stress response aging translational control translation elongation
ISSN:	1098-5549, 0270-7306, 1098-5549
On-line přístup:	Získat plný text
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