Are Quaternary Ammonium Compounds, the Workhorse Disinfectants, Effective against Severe Acute Respiratory Syndrome-Coronavirus-2?

A novel virus named Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) emerged from Wuhan, China in late 2019. Since then, the virus has quickly spread worldwide, leading the World Health Organization to declare it as a pandemic; by the end of April 2020, the number of cases exceeded 3 mil...

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Veröffentlicht in:ACS infectious diseases Jg. 6; H. 7; S. 1553
Hauptverfasser: Schrank, Cassandra L, Minbiole, Kevin P C, Wuest, William M
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 10.07.2020
Schlagworte:
Anti-Infective Agents, Local - pharmacology
Benzalkonium Compounds - pharmacology
Betacoronavirus - chemistry
Betacoronavirus - drug effects
Coronavirus Infections - prevention & control
Coronavirus Infections - virology
COVID-19
Disinfectants - pharmacology
Disinfection - methods
Hand Disinfection - methods
Humans
Membrane Lipids
Pandemics - prevention & control
Pneumonia, Viral - prevention & control
Pneumonia, Viral - virology
Sanitation - methods
SARS-CoV-2
Treatment Outcome
Virus Replication - drug effects
ISSN:2373-8227, 2373-8227
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Zusammenfassung:A novel virus named Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) emerged from Wuhan, China in late 2019. Since then, the virus has quickly spread worldwide, leading the World Health Organization to declare it as a pandemic; by the end of April 2020, the number of cases exceeded 3 million. Due to the high infectivity rate, SARS-CoV-2 is difficult to contain, making disinfectant protocols vital, especially for essential, highly trafficked areas such as hospitals, grocery stores, and delivery centers. According to the Centers for Disease Control and Prevention, best practices to slow the spread rely on good hand hygiene, including proper handwashing practices as well as the use of alcohol-based hand sanitizers. However, they provide warning against sanitizing products containing benzalkonium chloride (BAC), which has sparked concern in both the scientific community as well as the general public as BAC, a common quaternary ammonium compound (QAC), is ubiquitous in soaps and cleaning wipes as well as hospital sanitation kits. This viewpoint aims to highlight the outdated and incongruous data in the evaluation of BAC against the family of known coronaviruses and points to the need for further evaluation of the efficacy of QACs against coronaviruses.
Bibliographie:ObjectType-Article-1
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ISSN:2373-8227
2373-8227
DOI:10.1021/acsinfecdis.0c00265