Germline Mutations in Predisposition Genes in Pediatric Cancer

A constitutive mutation in a cancer-susceptibility gene can have implications for clinical treatment and genetic counseling of family members. This study involving 1120 children and adolescents showed that 95 (8.5%) had such a mutation. The frequency of germline mutations in cancer-predisposition ge...

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Veröffentlicht in:	The New England journal of medicine Jg. 373; H. 24; S. 2336 - 2346
Hauptverfasser:	Zhang, Jinghui, Walsh, Michael F, Wu, Gang, Edmonson, Michael N, Gruber, Tanja A, Easton, John, Hedges, Dale, Ma, Xiaotu, Zhou, Xin, Yergeau, Donald A, Wilkinson, Mark R, Vadodaria, Bhavin, Chen, Xiang, McGee, Rose B, Hines-Dowell, Stacy, Nuccio, Regina, Quinn, Emily, Shurtleff, Sheila A, Rusch, Michael, Patel, Aman, Becksfort, Jared B, Wang, Shuoguo, Weaver, Meaghann S, Ding, Li, Mardis, Elaine R, Wilson, Richard K, Gajjar, Amar, Ellison, David W, Pappo, Alberto S, Pui, Ching-Hon, Nichols, Kim E, Downing, James R
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Massachusetts Medical Society 10.12.2015
Schlagworte:	Adenomatous polyposis coli Adolescent Adolescents Autism Autistic Disorder - genetics BRCA2 protein Cancer Child Children Children & youth Computer applications Data processing Female Genes Genes, Dominant Genes, Neoplasm Genetic counseling Genetic Predisposition to Disease Genome, Human Genomes Germ-Line Mutation Humans Male Mutation Neoplasms - genetics Nucleotide sequence p53 Protein Pathogenesis Pathogenicity Pediatrics Runx1 protein SEER Program Sequence Analysis, DNA - methods Tumor suppressor genes Tumorigenesis Young Adult
ISSN:	0028-4793, 1533-4406, 1533-4406
Online-Zugang:	Volltext
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