Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy

Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. Fractions containing nitidine have in vitro 50% inhibitory concentrations against Plasmodium falciparum in...

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Published in:Antimicrobial agents and chemotherapy Vol. 39; no. 12; p. 2606
Main Authors: Gakunju, D M, Mberu, E K, Dossaji, S F, Gray, A I, Waigh, R D, Waterman, P G, Watkins, W M
Format: Journal Article
Language:English
Published: United States 01.12.1995
Subjects:
Animals
Antimalarials - chemistry
Antimalarials - isolation & purification
Antimalarials - pharmacology
Benzophenanthridines
Biological Assay
Drug Resistance
Kenya
Mass Spectrometry
Phenanthridines - chemistry
Phenanthridines - isolation & purification
Phenanthridines - pharmacology
Plant Extracts - analysis
Plants, Medicinal - chemistry
Plasmodium falciparum - drug effects
Kenya
ISSN:0066-4804
Online Access:Get more information
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Summary:Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. Fractions containing nitidine have in vitro 50% inhibitory concentrations against Plasmodium falciparum in the range of 9 to 108 ng/ml for a range of chloroquine-susceptible and -resistant strains. The results show a lack of cross-resistance between chloroquine and nitidine.
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ISSN:0066-4804
DOI:10.1128/aac.39.12.2606