Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy

Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. Fractions containing nitidine have in vitro 50% inhibitory concentrations against Plasmodium falciparum in...

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Vydané v:	Antimicrobial agents and chemotherapy Ročník 39; číslo 12; s. 2606
Hlavní autori:	Gakunju, D M, Mberu, E K, Dossaji, S F, Gray, A I, Waigh, R D, Waterman, P G, Watkins, W M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.12.1995
Predmet:	Animals Antimalarials - chemistry Antimalarials - isolation & purification Antimalarials - pharmacology Benzophenanthridines Biological Assay Drug Resistance Kenya Mass Spectrometry Phenanthridines - chemistry Phenanthridines - isolation & purification Phenanthridines - pharmacology Plant Extracts - analysis Plants, Medicinal - chemistry Plasmodium falciparum - drug effects Kenya
ISSN:	0066-4804
On-line prístup:	Zistit podrobnosti o prístupe
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