Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy

Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. Fractions containing nitidine have in vitro 50% inhibitory concentrations against Plasmodium falciparum in...

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Vydané v:Antimicrobial agents and chemotherapy Ročník 39; číslo 12; s. 2606
Hlavní autori: Gakunju, D M, Mberu, E K, Dossaji, S F, Gray, A I, Waigh, R D, Waterman, P G, Watkins, W M
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.12.1995
Predmet:
Animals
Antimalarials - chemistry
Antimalarials - isolation & purification
Antimalarials - pharmacology
Benzophenanthridines
Biological Assay
Drug Resistance
Kenya
Mass Spectrometry
Phenanthridines - chemistry
Phenanthridines - isolation & purification
Phenanthridines - pharmacology
Plant Extracts - analysis
Plants, Medicinal - chemistry
Plasmodium falciparum - drug effects
Kenya
ISSN:0066-4804
On-line prístup:Zistit podrobnosti o prístupe
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Abstract Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. Fractions containing nitidine have in vitro 50% inhibitory concentrations against Plasmodium falciparum in the range of 9 to 108 ng/ml for a range of chloroquine-susceptible and -resistant strains. The results show a lack of cross-resistance between chloroquine and nitidine.
AbstractList Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. Fractions containing nitidine have in vitro 50% inhibitory concentrations against Plasmodium falciparum in the range of 9 to 108 ng/ml for a range of chloroquine-susceptible and -resistant strains. The results show a lack of cross-resistance between chloroquine and nitidine.Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. Fractions containing nitidine have in vitro 50% inhibitory concentrations against Plasmodium falciparum in the range of 9 to 108 ng/ml for a range of chloroquine-susceptible and -resistant strains. The results show a lack of cross-resistance between chloroquine and nitidine.
Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. Fractions containing nitidine have in vitro 50% inhibitory concentrations against Plasmodium falciparum in the range of 9 to 108 ng/ml for a range of chloroquine-susceptible and -resistant strains. The results show a lack of cross-resistance between chloroquine and nitidine.
Author Mberu, E K
Gray, A I
Dossaji, S F
Gakunju, D M
Waigh, R D
Waterman, P G
Watkins, W M
Author_xml – sequence: 1
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  surname: Gakunju
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  organization: Ministry of Health, Nairobi, Kenya
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SubjectTerms Animals
Antimalarials - chemistry
Antimalarials - isolation & purification
Antimalarials - pharmacology
Benzophenanthridines
Biological Assay
Drug Resistance
Kenya
Mass Spectrometry
Phenanthridines - chemistry
Phenanthridines - isolation & purification
Phenanthridines - pharmacology
Plant Extracts - analysis
Plants, Medicinal - chemistry
Plasmodium falciparum - drug effects
Title Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy
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