Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

The innate immune system functions as the first line of defense against invading bacteria and viruses. In this context, the cGAS/STING [cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase/STING] signaling axis perceives the nonself DNA associated with bacterial and viral infe...

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Veröffentlicht in:	Annual review of biochemistry Jg. 86; S. 541
Hauptverfasser:	Kato, Kazuki, Omura, Hiroki, Ishitani, Ryuichiro, Nureki, Osamu
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 20.06.2017
Schlagworte:	Animals Bacteria Crystallography, X-Ray Cytosol - chemistry Cytosol - immunology DNA - chemistry DNA - genetics DNA - immunology Gene Expression Regulation Humans Immunity, Innate Interferon Regulatory Factor-3 - chemistry Interferon Regulatory Factor-3 - genetics Interferon Regulatory Factor-3 - immunology Models, Molecular Nucleotides, Cyclic - chemistry Nucleotides, Cyclic - genetics Nucleotides, Cyclic - immunology Nucleotidyltransferases - chemistry Nucleotidyltransferases - genetics Nucleotidyltransferases - immunology Phosphorylation Protein Conformation Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - immunology Second Messenger Systems - genetics Second Messenger Systems - immunology type I interferon cGAS STING cGAMP innate immune system
ISSN:	1545-4509, 1545-4509
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