Towards an understanding of the mechanism of pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites

The antifolate combination of pyrimethamine (PM) and sulfadoxine (SD) is the last affordable drug combination available for wide-scale treatment of falciparum malaria in Africa. Wherever this combination has been used, drug-resistant parasites have been selected rapidly. A study of PM-SD effectivene...

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Bibliographic Details
Published in:	Antimicrobial agents and chemotherapy Vol. 44; no. 4; p. 991
Main Authors:	Nzila, A M, Mberu, E K, Sulo, J, Dayo, H, Winstanley, P A, Sibley, C H, Watkins, W M
Format:	Journal Article
Language:	English
Published:	United States 01.04.2000
Subjects:	Alleles Animals Antimalarials - pharmacology Child, Preschool Dihydropteroate Synthase - genetics Drug Resistance Female Genotype Humans Infant Kenya Malaria, Falciparum - parasitology Male Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Pyrimethamine - pharmacology Sulfadoxine - pharmacology Tetrahydrofolate Dehydrogenase - genetics Kenya
ISSN:	0066-4804
Online Access:	Get more information
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