Sustained Replication of Synthetic Canine Distemper Virus Defective Genomes In Vitro and In Vivo

Defective interfering (DI) genomes have long been considered inconvenient artifacts that suppressed viral replication in vitro . However, advances in sequencing technologies have led to DI genomes being identified in clinical samples, implicating them in disease progression and outcome. Defective in...

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Bibliographic Details
Published in:	mSphere Vol. 6; no. 5; p. e0053721
Main Authors:	Tilston-Lunel, Natasha L., Welch, Stephen R., Nambulli, Sham, de Vries, Rory D., Ho, Gregory W., Wentworth, David E., Shabman, Reed, Nichol, Stuart T., Spiropoulou, Christina F., de Swart, Rik L., Rennick, Linda J., Duprex, W. Paul
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 27.10.2021
Subjects:	Adjuvants Animals Antiviral agents Antiviral drugs Canine distemper Cell Line Chlorocebus aethiops Defective Viruses Distemper Virus, Canine - genetics Distemper Virus, Canine - physiology Dogs Experiments Ferrets Genome, Viral Genomes Infections Influenza Inoculation Interferon Long-term effects Lymphoid tissue Male Mustela Next-generation sequencing Plasmids Proteins Raccoons - virology Replication Research Article RNA polymerase RNA viruses Vero Cells Virology Virus Replication - genetics Virus Replication - physiology Viruses single-step attenuation canine distemper virus next-generation sequencing vaccines defective interfering genomes defective genomes defective interfering viral particles ferret model
ISSN:	2379-5042, 2379-5042
Online Access:	Get full text
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