Short-Chain Fatty Acids as a Potential Treatment for Infections: a Closer Look at the Lungs
Short-chain fatty acids (SCFAs) are the main metabolites produced by the gut microbiota via the fermentation of complex carbohydrates and fibers. Evidence suggests that SCFAs play a role in the control of infections through direct action both on microorganisms and on host signaling. This review summ...
Gespeichert in:
| Veröffentlicht in: | Infection and immunity Jg. 89; H. 9; S. e0018821 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
16.08.2021
|
| Schlagworte: | |
| ISSN: | 1098-5522, 1098-5522 |
| Online-Zugang: | Weitere Angaben |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Short-chain fatty acids (SCFAs) are the main metabolites produced by the gut microbiota via the fermentation of complex carbohydrates and fibers. Evidence suggests that SCFAs play a role in the control of infections through direct action both on microorganisms and on host signaling. This review summarizes the main microbicidal effects of SCFAs and discusses studies highlighting the effect of SCFAs in the virulence and viability of microorganisms. We also describe the diverse and complex modes of action of the SCFAs on the immune system in the face of infections with a specific focus on bacterial and viral respiratory infections. A growing body of evidence suggests that SCFAs protect against lung infections. Finally, we present potential strategies that may be leveraged to exploit the biological properties of SCFAs for increasing effectiveness and optimizing patient benefits. |
|---|---|
| AbstractList | Short-chain fatty acids (SCFAs) are the main metabolites produced by the gut microbiota via the fermentation of complex carbohydrates and fibers. Evidence suggests that SCFAs play a role in the control of infections through direct action both on microorganisms and on host signaling. This review summarizes the main microbicidal effects of SCFAs and discusses studies highlighting the effect of SCFAs in the virulence and viability of microorganisms. We also describe the diverse and complex modes of action of the SCFAs on the immune system in the face of infections with a specific focus on bacterial and viral respiratory infections. A growing body of evidence suggests that SCFAs protect against lung infections. Finally, we present potential strategies that may be leveraged to exploit the biological properties of SCFAs for increasing effectiveness and optimizing patient benefits.Short-chain fatty acids (SCFAs) are the main metabolites produced by the gut microbiota via the fermentation of complex carbohydrates and fibers. Evidence suggests that SCFAs play a role in the control of infections through direct action both on microorganisms and on host signaling. This review summarizes the main microbicidal effects of SCFAs and discusses studies highlighting the effect of SCFAs in the virulence and viability of microorganisms. We also describe the diverse and complex modes of action of the SCFAs on the immune system in the face of infections with a specific focus on bacterial and viral respiratory infections. A growing body of evidence suggests that SCFAs protect against lung infections. Finally, we present potential strategies that may be leveraged to exploit the biological properties of SCFAs for increasing effectiveness and optimizing patient benefits. Short-chain fatty acids (SCFAs) are the main metabolites produced by the gut microbiota via the fermentation of complex carbohydrates and fibers. Evidence suggests that SCFAs play a role in the control of infections through direct action both on microorganisms and on host signaling. This review summarizes the main microbicidal effects of SCFAs and discusses studies highlighting the effect of SCFAs in the virulence and viability of microorganisms. We also describe the diverse and complex modes of action of the SCFAs on the immune system in the face of infections with a specific focus on bacterial and viral respiratory infections. A growing body of evidence suggests that SCFAs protect against lung infections. Finally, we present potential strategies that may be leveraged to exploit the biological properties of SCFAs for increasing effectiveness and optimizing patient benefits. |
| Author | Trottein, François Sencio, Valentin Machado, Marina Gomes |
| Author_xml | – sequence: 1 givenname: Marina Gomes surname: Machado fullname: Machado, Marina Gomes organization: Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, ICB, Federal University of Minas Gerais, Belo Horizonte, Brazil – sequence: 2 givenname: Valentin surname: Sencio fullname: Sencio, Valentin organization: Centre d'Infection et d'Immunité de Lille, INSERM U1019, CNRS UMR 9017, University of Lille, CHU Lille, Institut Pasteur de Lille, Lille, France – sequence: 3 givenname: François surname: Trottein fullname: Trottein, François organization: Centre d'Infection et d'Immunité de Lille, INSERM U1019, CNRS UMR 9017, University of Lille, CHU Lille, Institut Pasteur de Lille, Lille, France |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34097474$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkE1LxDAYhIOsuB968yw5eumapAlJvC3F1UJBwfXkoaTZ1FbbZE3Sw_57A64gDMw78DDwzhLMrLMGgGuM1hgTcVduyjVCWIiM4DOwwEiKjDFCZv_uOViG8JkoSqm4APOcIskppwvw_to5H7OiU72FWxXjEW50vw9QJcEXF42NvRrgzhsVxxRg6zwsbWt07J0N94kqBheMh5VzX1BFGDsDq8l-hEtw3qohmKuTr8Db9mFXPGXV82NZbKpMMYJjlgtNccOFFOkJqjluBeJEIIm1MI3ERjJJFOGoRSxneYNbRButWaNzQhVWZAVuf3sP3n1PJsR67IM2w6CscVOoCcslQUJwlNCbEzo1o9nXB9-Pyh_rv0HID0n3YUE |
| CitedBy_id | crossref_primary_10_3389_fimmu_2022_773261 crossref_primary_10_1016_j_ijbiomac_2024_131958 crossref_primary_10_3892_etm_2022_11536 crossref_primary_10_1111_1751_7915_70147 crossref_primary_10_1016_j_biopha_2023_115276 crossref_primary_10_1371_journal_ppat_1013453 crossref_primary_10_1080_19490976_2024_2361660 crossref_primary_10_1007_s40473_024_00292_9 crossref_primary_10_1159_000542807 crossref_primary_10_1016_j_ucl_2024_07_016 crossref_primary_10_1080_19490976_2021_2018900 crossref_primary_10_3389_fcimb_2023_1149679 crossref_primary_10_3389_fimmu_2024_1347676 crossref_primary_10_1038_s41598_024_78992_1 crossref_primary_10_3390_environments11070145 crossref_primary_10_1111_wrr_13208 crossref_primary_10_4014_jmb_2301_01031 crossref_primary_10_1016_j_fbio_2024_103665 crossref_primary_10_1016_j_micpath_2025_107835 crossref_primary_10_1186_s41231_024_00167_x crossref_primary_10_3390_nu14071478 crossref_primary_10_1016_j_tvjl_2025_106320 crossref_primary_10_3389_fnut_2024_1330903 crossref_primary_10_3390_ani15010103 crossref_primary_10_1007_s00216_022_04217_x crossref_primary_10_3390_ijms25094817 crossref_primary_10_1016_j_jaci_2024_04_029 crossref_primary_10_1016_j_tube_2025_102652 crossref_primary_10_3389_fcimb_2022_815715 crossref_primary_10_3389_fmicb_2023_1292266 crossref_primary_10_1016_j_biopha_2023_114414 crossref_primary_10_1016_j_cell_2025_08_001 crossref_primary_10_1016_j_tim_2024_10_001 crossref_primary_10_3390_ijms23094768 crossref_primary_10_1007_s00284_022_03029_7 crossref_primary_10_33073_pjm_2025_011 crossref_primary_10_1039_D4FO04028G crossref_primary_10_3389_fphar_2022_1020133 crossref_primary_10_1016_j_cbi_2022_110231 crossref_primary_10_3390_ijms24021716 crossref_primary_10_1038_s41598_023_45340_8 crossref_primary_10_3389_fmicb_2025_1632412 crossref_primary_10_1371_journal_pone_0313090 crossref_primary_10_1186_s12967_024_05376_4 crossref_primary_10_3390_jof11050333 crossref_primary_10_1016_j_jiph_2025_102840 crossref_primary_10_1016_j_biopha_2023_114916 crossref_primary_10_1016_j_imlet_2023_06_002 crossref_primary_10_1038_s41579_024_01058_6 crossref_primary_10_3389_fevo_2023_1126243 crossref_primary_10_3389_fimmu_2022_841532 crossref_primary_10_1016_j_fbio_2025_106914 crossref_primary_10_31083_j_fbl2902059 crossref_primary_10_3389_fmicb_2023_1125616 crossref_primary_10_3390_nu14235033 crossref_primary_10_1128_IAI_00356_21 crossref_primary_10_1186_s12964_025_02367_w crossref_primary_10_1016_j_jff_2025_107010 crossref_primary_10_1371_journal_ppat_1011160 crossref_primary_10_1016_j_addr_2023_114896 crossref_primary_10_3390_biomedicines12081779 crossref_primary_10_1038_s41467_022_35767_4 crossref_primary_10_1111_apha_14266 crossref_primary_10_1002_jmv_70192 crossref_primary_10_3390_nu16081159 crossref_primary_10_1002_fsn3_70292 crossref_primary_10_1038_s41579_024_01048_8 crossref_primary_10_3390_ijms23031022 crossref_primary_10_1016_j_aquaculture_2024_740581 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1128/IAI.00188-21 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1098-5522 |
| ExternalDocumentID | 34097474 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Review |
| GrantInformation_xml | – fundername: Agence Nationale de la Recherche (ANR) grantid: ANR-17-CE15-0020-01 – fundername: Agence Nationale de la Recherche (ANR) grantid: AM-COV-PATH |
| GroupedDBID | --- -DZ -~X .55 0R~ 18M 29I 2WC 39C 4.4 53G 5GY 5RE 5VS 85S ABOCM ACGFO ADBBV AENEX AGVNZ ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BTFSW CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF F5P FRP GX1 H13 HYE HZ~ IH2 KQ8 L7B NPM O9- OK1 P2P RHF RHI RNS RPM RSF SJN TR2 TWZ UCJ UPT VQA W2D W8F WH7 WOQ X7M YIF ~KM 7X8 AAGFI |
| ID | FETCH-LOGICAL-a521t-38c41b78981884c71f80728091c8eb91e9592a270f05353b1f04bcc5bc324a1a2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 83 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000707999200007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1098-5522 |
| IngestDate | Wed Oct 01 13:41:09 EDT 2025 Wed Feb 19 02:26:33 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Keywords | short-chain fatty acid bacteria virus gut respiratory infection |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-a521t-38c41b78981884c71f80728091c8eb91e9592a270f05353b1f04bcc5bc324a1a2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/8370681 |
| PMID | 34097474 |
| PQID | 2539208870 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2539208870 pubmed_primary_34097474 |
| PublicationCentury | 2000 |
| PublicationDate | 20210816 |
| PublicationDateYYYYMMDD | 2021-08-16 |
| PublicationDate_xml | – month: 8 year: 2021 text: 20210816 day: 16 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Infection and immunity |
| PublicationTitleAlternate | Infect Immun |
| PublicationYear | 2021 |
| SSID | ssj0014448 |
| Score | 2.6050155 |
| SecondaryResourceType | review_article |
| Snippet | Short-chain fatty acids (SCFAs) are the main metabolites produced by the gut microbiota via the fermentation of complex carbohydrates and fibers. Evidence... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | e0018821 |
| SubjectTerms | Animals Anti-Infective Agents - immunology Anti-Infective Agents - metabolism Anti-Infective Agents - therapeutic use Fatty Acids, Volatile - immunology Fatty Acids, Volatile - metabolism Fatty Acids, Volatile - therapeutic use Humans Infections - drug therapy Infections - immunology Infections - microbiology Lung - drug effects Lung - immunology Lung - microbiology Lung - virology Microbial Viability Respiratory Tract Infections - drug therapy Respiratory Tract Infections - immunology Respiratory Tract Infections - microbiology Respiratory Tract Infections - virology Signal Transduction - immunology Virulence |
| Title | Short-Chain Fatty Acids as a Potential Treatment for Infections: a Closer Look at the Lungs |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/34097474 https://www.proquest.com/docview/2539208870 |
| Volume | 89 |
| WOSCitedRecordID | wos000707999200007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bS8MwFA7qVHzxfpk3IvgabNqkTXyRMRwOtjHwwsCHkmYNDqRVW4X9e89ZW3wSBKGUPqSlJOfykfPlfIRcBkEoQhlx5pwvmbDwlISaM5VMIy7d1JlFK6WnQTQaqclEj-sNt6KmVTYxcRGop7nFPfIrX0ImR5fwbt7eGapGYXW1ltBYJq0AoAw6ZjT5qSIIIaqjcFoxCUCjIb776qrf6WMRAs2E_w4uF0mmt_Xf39smmzW8pJ3KHnbIUprtkrVKcHK-S9aHdSl9jzzfvwDyZt0XM8toz5TlnHbsbFpQAxcd5yXSiOBTDw0TnQK8pf2au5UV1zCq-5qDBdMBAHVqSgpYkg4geBT75LF3-9C9Y7XSAjMoaMACZQVPIqUhfStcMKc81K3S3Ko00TzVUvvGjzyH7WCChDtPJNbKxAIeM9z4B2Qly7P0iFCrnGeUdIEEpOXrUIWpiwKNJ3CVNca2yUUzgTFYMpYnTJbmn0X8M4VtclitQvxWtdyIA2zLJSJx_Ie3T8iGj8QT7FsbnpKWAz9Oz8iq_Spnxcf5wkTgPhoPvwEpCMKp |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Short-Chain+Fatty+Acids+as+a+Potential+Treatment+for+Infections%3A+a+Closer+Look+at+the+Lungs&rft.jtitle=Infection+and+immunity&rft.au=Machado%2C+Marina+Gomes&rft.au=Sencio%2C+Valentin&rft.au=Trottein%2C+Fran%C3%A7ois&rft.date=2021-08-16&rft.issn=1098-5522&rft.eissn=1098-5522&rft.volume=89&rft.issue=9&rft.spage=e0018821&rft_id=info:doi/10.1128%2FIAI.00188-21&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1098-5522&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1098-5522&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1098-5522&client=summon |