Emergence of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae Strains in China

We report the emergence of five carbapenem-resistant K1 hypervirulent Klebsiella pneumoniae (hvKP) strains which caused fatal infections in hospital patients in Zhejiang Province, China, upon entry through surgical wounds. Genotyping results revealed the existence of three genetically related strain...

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Vydáno v:Antimicrobial agents and chemotherapy Ročník 60; číslo 1; s. 709
Hlavní autoři: Zhang, Rong, Lin, Dachuan, Chan, Edward Wai-Chi, Gu, Danxia, Chen, Gong-Xiang, Chen, Sheng
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.01.2016
Témata:
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - pharmacology
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
beta-Lactam Resistance - genetics
beta-Lactamases - genetics
beta-Lactamases - metabolism
Carbapenems - pharmacology
Carbohydrate Epimerases - genetics
Carbohydrate Epimerases - metabolism
China
Female
Genotype
Humans
Klebsiella Infections - drug therapy
Klebsiella Infections - microbiology
Klebsiella Infections - mortality
Klebsiella Infections - pathology
Klebsiella pneumoniae - drug effects
Klebsiella pneumoniae - genetics
Klebsiella pneumoniae - isolation & purification
Klebsiella pneumoniae - pathogenicity
Male
Middle Aged
Multilocus Sequence Typing
Plasmids - chemistry
Plasmids - metabolism
Serogroup
Survival Analysis
Virulence
China
ISSN:1098-6596, 1098-6596
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Shrnutí:We report the emergence of five carbapenem-resistant K1 hypervirulent Klebsiella pneumoniae (hvKP) strains which caused fatal infections in hospital patients in Zhejiang Province, China, upon entry through surgical wounds. Genotyping results revealed the existence of three genetically related strains which exhibited a new sequence type, ST1797, and revealed that all strains harbored the magA and wcaG virulence genes and a plasmid-borne bla(KPC-2) gene. These findings indicate that K1 hvKP is simultaneously hypervirulent, multidrug resistant, and transmissible.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1098-6596
1098-6596
DOI:10.1128/AAC.02173-15