The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface

Protein regions that are involved in protein-protein interactions (PPIs) very often display a high degree of intrinsic disorder, which is reduced during the recognition process. A prime example is binding of the rigid 14-3-3 adapter proteins to their numerous partner proteins, whose recognition moti...

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Bibliographic Details
Published in:	Journal of the American Chemical Society Vol. 139; no. 45; p. 16256
Main Authors:	Bier, David, Mittal, Sumit, Bravo-Rodriguez, Kenny, Sowislok, Andrea, Guillory, Xavier, Briels, Jeroen, Heid, Christian, Bartel, Maria, Wettig, Burkhard, Brunsveld, Luc, Sanchez-Garcia, Elsa, Schrader, Thomas, Ottmann, Christian
Format:	Journal Article
Language:	English
Published:	United States 15.11.2017
Subjects:	14-3-3 Proteins - chemistry 14-3-3 Proteins - metabolism Amino Acid Motifs Binding Sites cdc25 Phosphatases - chemistry cdc25 Phosphatases - metabolism Entropy Intrinsically Disordered Proteins - chemistry Intrinsically Disordered Proteins - metabolism Ligands Models, Molecular Peptides - chemistry Peptides - metabolism Protein Binding Protein Conformation Protein Stability
ISSN:	1520-5126, 1520-5126
Online Access:	Get more information
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