Bioinformatic Expansion and Discovery of Thiopeptide Antibiotics

Thiopeptides are members of the ribosomally synthesized and post-translationally modified peptide family of natural products. Most characterized thiopeptides display nanomolar potency toward Gram-positive bacteria by blocking protein translation with several being produced at the industrial scale fo...

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Bibliographic Details
Published in:	Journal of the American Chemical Society Vol. 140; no. 30; pp. 9494 - 9501
Main Authors:	Schwalen, Christopher J., Hudson, Graham A., Kille, Bryce, Mitchell, Douglas A.
Format:	Journal Article
Language:	English
Published:	WASHINGTON Amer Chemical Soc 01.08.2018
Subjects:	Actinobacteria - chemistry Actinobacteria - genetics Algorithms Amino Acid Sequence Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - classification Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Bacillus subtilis - drug effects Chemistry Chemistry, Multidisciplinary Computational Biology Databases, Genetic Enterococcus faecium - drug effects Lyases - genetics Markov Chains Methicillin-Resistant Staphylococcus aureus - drug effects Multigene Family Peptides, Cyclic - classification Peptides, Cyclic - genetics Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Physical Sciences Protein Processing, Post-Translational Science & Technology Thioamides - chemistry Whole Genome Sequencing BERNINAMYCIN COMPLEX DATABASE CLONING BIOSYNTHESIS COMPOUND THIOSTREPTON INHIBITOR THIOVIRIDAMIDE ATP
ISSN:	0002-7863, 1520-5126, 1520-5126
Online Access:	Get more information
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