Pharmacology of Antisense Drugs

Recent studies have led to a greater appreciation of the diverse roles RNAs play in maintaining normal cellular function and how they contribute to disease pathology, broadening the number of potential therapeutic targets. Antisense oligonucleotides are the most direct means to target RNA in a selec...

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Bibliographic Details
Published in:	Annual review of pharmacology and toxicology Vol. 57; pp. 81 - 105
Main Authors:	Bennett, C Frank, Baker, Brenda F, Pham, Nguyen, Swayze, Eric, Geary, Richard S
Format:	Journal Article
Language:	English
Published:	United States 06.01.2017
Subjects:	Animals Autoimmune Diseases - drug therapy Autoimmune Diseases - metabolism Cardiovascular Diseases - drug therapy Cardiovascular Diseases - metabolism Humans Oligonucleotides, Antisense - metabolism Oligonucleotides, Antisense - pharmacology Oligonucleotides, Antisense - therapeutic use RNA Interference - drug effects RNA Interference - physiology RNA Splicing - drug effects RNA Splicing - physiology RNA interference RNA eteplirsen antisense oligonucleotides RNase H nusinersen patisiran mipomersen RNA splicing oligonucleotide
ISSN:	1545-4304
Online Access:	Get more information
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