The Genetic Architecture of Obsessive-Compulsive Disorder: Contribution of Liability to OCD From Alleles Across the Frequency Spectrum

Obsessive-compulsive disorder (OCD) is known to be substantially heritable; however, the contribution of genetic variation across the allele frequency spectrum to this heritability remains uncertain. The authors used two new homogeneous cohorts to estimate the heritability of OCD from inherited gene...

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Veröffentlicht in:	The American journal of psychiatry Jg. 179; H. 3; S. 216
Hauptverfasser:	Mahjani, Behrang, Klei, Lambertus, Mattheisen, Manuel, Halvorsen, Matthew W, Reichenberg, Abraham, Roeder, Kathryn, Pedersen, Nancy L, Boberg, Julia, de Schipper, Elles, Bulik, Cynthia M, Landén, Mikael, Fundín, Bengt, Mataix-Cols, David, Sandin, Sven, Hultman, Christina M, Crowley, James J, Buxbaum, Joseph D, Rück, Christian, Devlin, Bernie, Grice, Dorothy E
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.03.2022
Schlagworte:	Alleles Genome-Wide Association Study - methods Humans Multifactorial Inheritance Obsessive-Compulsive Disorder - diagnosis Obsessive-Compulsive Disorder - genetics Polymorphism, Single Nucleotide - genetics Obsessive-Compulsive Disorder Genetics Heritability
ISSN:	1535-7228, 1535-7228
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