Polymeric Nanoparticles for Drug Delivery

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated the creation of more sophisticated drug delivery systems. Polymeric nanoparticles sit at the forefront of numerous promising drug delivery designs, due to their unmatched control over physiochemical pr...

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Veröffentlicht in:Chemical reviews Jg. 124; H. 9; S. 5505
Hauptverfasser: Beach, Maximilian A, Nayanathara, Umeka, Gao, Yanting, Zhang, Changhe, Xiong, Yijun, Wang, Yufu, Such, Georgina K
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 08.05.2024
Schlagworte:
Animals
Drug Carriers - chemistry
Drug Delivery Systems
Humans
Nanoparticles - chemistry
Neoplasms - drug therapy
Polymers - chemistry
ISSN:1520-6890, 1520-6890
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Zusammenfassung:The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated the creation of more sophisticated drug delivery systems. Polymeric nanoparticles sit at the forefront of numerous promising drug delivery designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, and surface functionality. Furthermore, polymeric nanoparticles have the ability to navigate various biological barriers to precisely target specific sites within the body, encapsulate a diverse range of therapeutic cargo and efficiently release this cargo in response to internal and external stimuli. However, despite these remarkable advantages, the presence of polymeric nanoparticles in wider clinical application is minimal. This review will provide a comprehensive understanding of polymeric nanoparticles as drug delivery vehicles. The biological barriers affecting drug delivery will be outlined first, followed by a comprehensive description of the various nanoparticle designs and preparation methods, beginning with the polymers on which they are based. The review will meticulously explore the current performance of polymeric nanoparticles against a myriad of diseases including cancer, viral and bacterial infections, before finally evaluating the advantages and crucial challenges that will determine their wider clinical potential in the decades to come.
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ISSN:1520-6890
1520-6890
DOI:10.1021/acs.chemrev.3c00705