The Noncell Autonomous Requirement of Proboscipedia for Growth and Differentiation of the Distal Maxillary Palp during Metamorphosis of Drosophila melanogaster

The Drosophila maxillary palpus that develops during metamorphosis is composed of two elements: the proximal maxillary socket and distal maxillary palp. The HOX protein, Proboscipedia (PB), was required for development of the proximal maxillary socket and distal maxillary palp. For growth and differ...

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Veröffentlicht in:Genetics Research International Jg. 2017; S. 1 - 14-002
Hauptverfasser: Percival-Smith, Anthony, Ponce, Gabriel, Pelling, Jacob J. H.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Egypt Hindawi Limiteds 01.01.2017
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Schlagworte:
Cloning
Drosophila
Exports
Gene expression
Gene regulation
Genetic aspects
Growth
Growth factors
HOX protein
Insects
Maxilla
Metamorphosis
Microscopy
Proteins
Transcription factors
ISSN:2090-3154, 2090-3162, 2090-3162
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Zusammenfassung:The Drosophila maxillary palpus that develops during metamorphosis is composed of two elements: the proximal maxillary socket and distal maxillary palp. The HOX protein, Proboscipedia (PB), was required for development of the proximal maxillary socket and distal maxillary palp. For growth and differentiation of the distal maxillary palp, PB was required in the cells of, or close to, the maxillary socket, as well as the cells of the distal maxillary palp. Therefore, PB is required in cells outside the distal maxillary palp for the expression, by some mechanism, of a growth factor or factors that promote the growth of the distal maxillary palp. Both wingless (wg) and hedgehog (hh) genes were expressed in cells outside the distal maxillary palp in the lancinia and maxillary socket, respectively. Both wg and hh were required for distal maxillary palp growth, and hh was required noncell autonomously for distal maxillary palp growth. However, expression of wg-GAL4 and hh-GAL4 during maxillary palp differentiation did not require PB, ruling out a direct role for PB in the regulation of transcription of these growth factors.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Academic Editor: Norman A. Doggett
ISSN:2090-3154
2090-3162
2090-3162
DOI:10.1155/2017/2624170