A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry

Eukaryotic DNA is methylated at some cytosine residues, and this epigenetic feature performs critical functions. We developed a method for quantitative determination of 5-methyl-2'-deoxycytidine in human DNA using liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS). The...

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Bibliographic Details

Published in:	Analytical chemistry (Washington) Vol. 74; no. 17; p. 4526
Main Authors:	Friso, Simonetta, Choi, Sang-Woon, Dolnikowski, Gregory G, Selhub, Jacob
Format:	Journal Article
Language:	English
Published:	United States 01.09.2002
Subjects:	Chromatography, High Pressure Liquid - methods Deoxycytidine - analogs & derivatives Deoxycytidine - analysis DNA - analysis DNA Methylation Genome Humans Online Systems Reproducibility of Results Spectrometry, Mass, Electrospray Ionization - instrumentation Spectrometry, Mass, Electrospray Ionization - methods
ISSN:	0003-2700
Online Access:	Get more information
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