Pharmacokinetics of aztreonam in healthy subjects and patients with cystic fibrosis and evaluation of dose-exposure relationships using monte carlo simulation

Aztreonam (AZM) is a monobactam antibiotic with a high level of activity against gram-negative micro-organisms, including Pseudomonas aeruginosa. We evaluated AZM pharmacokinetics and pharmacokinetic-pharmacodynamic relationships in patients with cystic fibrosis (CF) and healthy subjects. Pharmacoki...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy Jg. 51; H. 9; S. 3049
Hauptverfasser:	Vinks, Alexander A, van Rossem, Ronald N, Mathôt, Ron A A, Heijerman, Harry G M, Mouton, Johan W
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.09.2007
Schlagworte:	Adult Algorithms Anti-Bacterial Agents - cerebrospinal fluid Anti-Bacterial Agents - pharmacokinetics Aztreonam - cerebrospinal fluid Aztreonam - pharmacokinetics Cystic Fibrosis - metabolism Dose-Response Relationship, Drug Female Half-Life Humans Male Models, Statistical Monte Carlo Method
ISSN:	0066-4804
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