1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity

1592U89, (-)-(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclo pentene-1-methanol, is a carbocyclic nucleoside with a unique biological profile giving potent, selective anti-human immunodeficiency virus (HIV) activity. 1592U89 was selected after evaluation of a wide variety of analogs c...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy Jg. 41; H. 5; S. 1082
Hauptverfasser:	Daluge, S M, Good, S S, Faletto, M B, Miller, W H, St Clair, M H, Boone, L R, Tisdale, M, Parry, N R, Reardon, J E, Dornsife, R E, Averett, D R, Krenitsky, T A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.05.1997
Schlagworte:	Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - metabolism Adenosine Deaminase - metabolism Administration, Oral Animals Anti-HIV Agents - blood Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacokinetics Anti-HIV Agents - urine Antiviral Agents - blood Antiviral Agents - pharmacokinetics Area Under Curve Biotransformation Cells, Cultured Dideoxynucleosides - blood Dideoxynucleosides - chemistry Dideoxynucleosides - pharmacokinetics Dideoxynucleosides - urine Drug Resistance, Microbial Female Half-Life HIV-1 - drug effects Humans Injections, Intravenous Macaca fascicularis Male Rats Structure-Activity Relationship
ISSN:	0066-4804
Online-Zugang:	Weitere Angaben
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