trans-Fluorine Effect in Cyclopropane: Diastereoselective Synthesis of Fluorocyclopropyl Cabozantinib Analogs

Investigation of the trans-fluorine effect on the hydrolysis rate of diethyl 2-fluorocyclopropane-1,1-dicarboxylate provides synthetic access to both diastereomers of the fluorocyclopropyl analog of cabozantinib, a c-Met and VEGFR-2 inhibitor used as a first-line treatment for thyroid cancer and as...

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Bibliographic Details

Published in:	ACS medicinal chemistry letters Vol. 11; no. 11; pp. 2146 - 2150
Main Authors:	Veliks, Janis, Videja, Melita, Kinens, Artis, Bobrovs, Raitis, Priede, Martins, Kuka, Janis
Format:	Journal Article
Language:	English
Published:	WASHINGTON Amer Chemical Soc 12.11.2020
Subjects:	Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology c-Met kinase inhibitors fluorocyclopropane VEGFR-2 kinase inhibitors anticancer cabozantinib
ISSN:	1948-5875, 1948-5875
Online Access:	Get more information
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