Identification of Crucial Amino Acid Residues Involved in Agonist Signaling at the GPR55 Receptor

GPR55 is a newly deorphanized class A G-protein-coupled receptor that has been implicated in inflammatory pain, neuropathic pain, metabolic disorder, bone development, and cancer. Few potent GPR55 ligands have been identified to date. This is largely due to an absence of information about salient fe...

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Veröffentlicht in:	Biochemistry (Easton) Jg. 56; H. 3; S. 473
Hauptverfasser:	Lingerfelt, Mary A, Zhao, Pingwei, Sharir, Haleli P, Hurst, Dow P, Reggio, Patricia H, Abood, Mary E
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 24.01.2017
Schlagworte:	Amino Acid Motifs Binding Sites Crystallography, X-Ray Gene Expression Glycine max HEK293 Cells Humans Kinetics Ligands Lysophospholipids - chemistry Lysophospholipids - pharmacology Molecular Docking Simulation Mutation Piperazines - chemistry Piperazines - pharmacology Protein Binding Pyrrolidines - chemistry Pyrrolidines - pharmacology Receptors, Cannabinoid Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, Opioid, delta - chemistry Receptors, Opioid, delta - genetics Receptors, Opioid, delta - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Serum Response Element Serum Response Factor - chemistry Serum Response Factor - genetics Serum Response Factor - metabolism Signal Transduction Structural Homology, Protein Thermodynamics
ISSN:	1520-4995, 1520-4995
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