Inactivation of SARS-CoV-2 in the Liquid Phase: Are Aqueous Hydrogen Peroxide and Sodium Percarbonate Efficient Decontamination Agents?

A diluted 3% w/w hydrogen peroxide solution acidified to pH 2.5 by adding citric acid inactivated SARS-CoV-2 virus by more than 4 orders of magnitude in 5 min. After a contact time of 15 min, no viral replication was detected. Aqueous solutions of sodium percarbonate inactivated coronavirus by >3...

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Vydané v:ACS Chemical Health & Safety. Ročník 28; číslo 4; s. 260
Hlavní autori: Mileto, Davide, Mancon, Alessandro, Staurenghi, Federica, Rizzo, Alberto, Econdi, Stefano, Gismondo, Maria Rita, Guidotti, Matteo
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 26.07.2021
ISSN:1878-0504, 1878-0504
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Abstract A diluted 3% w/w hydrogen peroxide solution acidified to pH 2.5 by adding citric acid inactivated SARS-CoV-2 virus by more than 4 orders of magnitude in 5 min. After a contact time of 15 min, no viral replication was detected. Aqueous solutions of sodium percarbonate inactivated coronavirus by >3 log diminution in 15 min. Conversely, H O solutions with no additives displayed a scarce virucidal activity (1.1 log diminution in 5 min), confirming that a pH-modifying ingredient is necessary to have a H O -based disinfectant active against the novel coronavirus.
AbstractList A diluted 3% w/w hydrogen peroxide solution acidified to pH 2.5 by adding citric acid inactivated SARS-CoV-2 virus by more than 4 orders of magnitude in 5 min. After a contact time of 15 min, no viral replication was detected. Aqueous solutions of sodium percarbonate inactivated coronavirus by >3 log10 diminution in 15 min. Conversely, H2O2 solutions with no additives displayed a scarce virucidal activity (1.1 log10 diminution in 5 min), confirming that a pH-modifying ingredient is necessary to have a H2O2-based disinfectant active against the novel coronavirus.A diluted 3% w/w hydrogen peroxide solution acidified to pH 2.5 by adding citric acid inactivated SARS-CoV-2 virus by more than 4 orders of magnitude in 5 min. After a contact time of 15 min, no viral replication was detected. Aqueous solutions of sodium percarbonate inactivated coronavirus by >3 log10 diminution in 15 min. Conversely, H2O2 solutions with no additives displayed a scarce virucidal activity (1.1 log10 diminution in 5 min), confirming that a pH-modifying ingredient is necessary to have a H2O2-based disinfectant active against the novel coronavirus.
A diluted 3% w/w hydrogen peroxide solution acidified to pH 2.5 by adding citric acid inactivated SARS-CoV-2 virus by more than 4 orders of magnitude in 5 min. After a contact time of 15 min, no viral replication was detected. Aqueous solutions of sodium percarbonate inactivated coronavirus by >3 log diminution in 15 min. Conversely, H O solutions with no additives displayed a scarce virucidal activity (1.1 log diminution in 5 min), confirming that a pH-modifying ingredient is necessary to have a H O -based disinfectant active against the novel coronavirus.
Author Mileto, Davide
Guidotti, Matteo
Rizzo, Alberto
Gismondo, Maria Rita
Econdi, Stefano
Mancon, Alessandro
Staurenghi, Federica
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Snippet A diluted 3% w/w hydrogen peroxide solution acidified to pH 2.5 by adding citric acid inactivated SARS-CoV-2 virus by more than 4 orders of magnitude in 5 min....
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Title Inactivation of SARS-CoV-2 in the Liquid Phase: Are Aqueous Hydrogen Peroxide and Sodium Percarbonate Efficient Decontamination Agents?
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