Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain

Sixty-nine Kenyan Plasmodium falciparum field isolates were tested in vitro against pyrimethamine (PM), chlorcycloguanil (CCG), sulfadoxine (SD), and dapsone (DDS), and their dihydrofolate reductase (DHFR) genotypes were determined. The in vitro data show that CCG is more potent than PM and that DDS...

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Bibliographic Details
Published in:	Antimicrobial agents and chemotherapy Vol. 42; no. 1; p. 164
Main Authors:	Nzila-Mounda, A, Mberu, E K, Sibley, C H, Plowe, C V, Winstanley, P A, Watkins, W M
Format:	Journal Article
Language:	English
Published:	United States 01.01.1998
Subjects:	Animals Antimalarials - pharmacology Humans Kenya Malaria, Falciparum - drug therapy Plasmodium falciparum - drug effects Plasmodium falciparum - enzymology Point Mutation Proguanil - analogs & derivatives Proguanil - pharmacology Protozoan Proteins - drug effects Protozoan Proteins - genetics Pyrimethamine - pharmacology Sensitivity and Specificity Tetrahydrofolate Dehydrogenase - drug effects Tetrahydrofolate Dehydrogenase - genetics Triazines Kenya
ISSN:	0066-4804
Online Access:	Get more information
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