Manganese Is Essential for Neuronal Health

The understanding of manganese (Mn) biology, in particular its cellular regulation and role in neurological disease, is an area of expanding interest. Mn is an essential micronutrient that is required for the activity of a diverse set of enzymatic proteins (e.g., arginase and glutamine synthase). Al...

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Veröffentlicht in:	Annual review of nutrition Jg. 35; S. 71
Hauptverfasser:	Horning, Kyle J, Caito, Samuel W, Tipps, K Grace, Bowman, Aaron B, Aschner, Michael
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 17.07.2015
Schlagworte:	Arginase - metabolism Bile - metabolism Blood-Brain Barrier Brain - physiology Enzyme Activation - physiology Glutamate-Ammonia Ligase - metabolism Health Status Homeostasis Humans Huntington Disease Intestinal Absorption Manganese - pharmacology Manganese - physiology Manganese - toxicity Nervous System Diseases Neurons - physiology Parkinson Disease blood-brain barrier homeostasis intracellular trafficking neurodevelopment cofactor metal transport
ISSN:	1545-4312, 1545-4312
Online-Zugang:	Weitere Angaben
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Abstract	The understanding of manganese (Mn) biology, in particular its cellular regulation and role in neurological disease, is an area of expanding interest. Mn is an essential micronutrient that is required for the activity of a diverse set of enzymatic proteins (e.g., arginase and glutamine synthase). Although necessary for life, Mn is toxic in excess. Thus, maintaining appropriate levels of intracellular Mn is critical. Unlike other essential metals, cell-level homeostatic mechanisms of Mn have not been identified. In this review, we discuss common forms of Mn exposure, absorption, and transport via regulated uptake/exchange at the gut and blood-brain barrier and via biliary excretion. We present the current understanding of cellular uptake and efflux as well as subcellular storage and transport of Mn. In addition, we highlight the Mn-dependent and Mn-responsive pathways implicated in the growing evidence of its role in Parkinson's disease and Huntington's disease. We conclude with suggestions for future focuses of Mn health-related research.
AbstractList	The understanding of manganese (Mn) biology, in particular its cellular regulation and role in neurological disease, is an area of expanding interest. Mn is an essential micronutrient that is required for the activity of a diverse set of enzymatic proteins (e.g., arginase and glutamine synthase). Although necessary for life, Mn is toxic in excess. Thus, maintaining appropriate levels of intracellular Mn is critical. Unlike other essential metals, cell-level homeostatic mechanisms of Mn have not been identified. In this review, we discuss common forms of Mn exposure, absorption, and transport via regulated uptake/exchange at the gut and blood-brain barrier and via biliary excretion. We present the current understanding of cellular uptake and efflux as well as subcellular storage and transport of Mn. In addition, we highlight the Mn-dependent and Mn-responsive pathways implicated in the growing evidence of its role in Parkinson's disease and Huntington's disease. We conclude with suggestions for future focuses of Mn health-related research. The understanding of manganese (Mn) biology, in particular its cellular regulation and role in neurological disease, is an area of expanding interest. Mn is an essential micronutrient that is required for the activity of a diverse set of enzymatic proteins (e.g., arginase and glutamine synthase). Although necessary for life, Mn is toxic in excess. Thus, maintaining appropriate levels of intracellular Mn is critical. Unlike other essential metals, cell-level homeostatic mechanisms of Mn have not been identified. In this review, we discuss common forms of Mn exposure, absorption, and transport via regulated uptake/exchange at the gut and blood-brain barrier and via biliary excretion. We present the current understanding of cellular uptake and efflux as well as subcellular storage and transport of Mn. In addition, we highlight the Mn-dependent and Mn-responsive pathways implicated in the growing evidence of its role in Parkinson's disease and Huntington's disease. We conclude with suggestions for future focuses of Mn health-related research.The understanding of manganese (Mn) biology, in particular its cellular regulation and role in neurological disease, is an area of expanding interest. Mn is an essential micronutrient that is required for the activity of a diverse set of enzymatic proteins (e.g., arginase and glutamine synthase). Although necessary for life, Mn is toxic in excess. Thus, maintaining appropriate levels of intracellular Mn is critical. Unlike other essential metals, cell-level homeostatic mechanisms of Mn have not been identified. In this review, we discuss common forms of Mn exposure, absorption, and transport via regulated uptake/exchange at the gut and blood-brain barrier and via biliary excretion. We present the current understanding of cellular uptake and efflux as well as subcellular storage and transport of Mn. In addition, we highlight the Mn-dependent and Mn-responsive pathways implicated in the growing evidence of its role in Parkinson's disease and Huntington's disease. We conclude with suggestions for future focuses of Mn health-related research.
Author	Horning, Kyle J Aschner, Michael Bowman, Aaron B Tipps, K Grace Caito, Samuel W
Author_xml	– sequence: 1 givenname: Kyle J surname: Horning fullname: Horning, Kyle J email: kyle.j.horning@vanderbilt.edu, k.grace.tipps@vanderbilt.edu, aaron.bowman@vanderbilt.edu organization: Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232; email: kyle.j.horning@vanderbilt.edu , k.grace.tipps@vanderbilt.edu , aaron.bowman@vanderbilt.edu – sequence: 2 givenname: Samuel W surname: Caito fullname: Caito, Samuel W – sequence: 3 givenname: K Grace surname: Tipps fullname: Tipps, K Grace – sequence: 4 givenname: Aaron B surname: Bowman fullname: Bowman, Aaron B – sequence: 5 givenname: Michael surname: Aschner fullname: Aschner, Michael
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25974698$$D View this record in MEDLINE/PubMed
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Snippet	The understanding of manganese (Mn) biology, in particular its cellular regulation and role in neurological disease, is an area of expanding interest. Mn is an...
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SubjectTerms	Arginase - metabolism Bile - metabolism Blood-Brain Barrier Brain - physiology Enzyme Activation - physiology Glutamate-Ammonia Ligase - metabolism Health Status Homeostasis Humans Huntington Disease Intestinal Absorption Manganese - pharmacology Manganese - physiology Manganese - toxicity Nervous System Diseases Neurons - physiology Parkinson Disease
Title	Manganese Is Essential for Neuronal Health
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