Imaging of Liver Tumors Using Surface-Enhanced Raman Scattering Nanoparticles
Complete surgical resection is the ideal first-line treatment for most liver malignancies. This goal would be facilitated by an intraoperative imaging method that enables more precise visualization of tumor margins and detection of otherwise invisible microscopic lesions. To this end, we synthesized...
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| Vydáno v: | ACS nano Ročník 10; číslo 5; s. 5015 - 5026 |
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| Médium: | Journal Article |
| Jazyk: | angličtina |
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American Chemical Society
24.05.2016
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| ISSN: | 1936-0851, 1936-086X, 1936-086X |
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| Abstract | Complete surgical resection is the ideal first-line treatment for most liver malignancies. This goal would be facilitated by an intraoperative imaging method that enables more precise visualization of tumor margins and detection of otherwise invisible microscopic lesions. To this end, we synthesized silica-encapsulated surface-enhanced Raman scattering (SERS) nanoparticles (NPs) that act as a molecular imaging agent for liver malignancies. We hypothesized that, after intravenous administration, SERS NPs would avidly home to healthy liver tissue but not to intrahepatic malignancies. We tested these SERS NPs in genetically engineered mouse models of hepatocellular carcinoma and histiocytic sarcoma. After intravenous injection, liver tumors in both models were readily identifiable with Raman imaging. In addition, Raman imaging using SERS NPs enabled detection of microscopic lesions in liver and spleen. We compared the performance of SERS NPs to fluorescence imaging using indocyanine green (ICG). We found that SERS NPs delineate tumors more accurately and are less susceptible to photobleaching. Given the known advantages of SERS imaging, namely, high sensitivity and specific spectroscopic detection, these findings hold promise for improved resection of liver cancer. |
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| AbstractList | Complete surgical resection is the ideal first-line treatment for most liver malignancies. This goal would be facilitated by an intraoperative imaging method that enables more precise visualization of tumor margins and detection of otherwise invisible microscopic lesions. To this end, we synthesized silica-encapsulated surface-enhanced Raman scattering (SERS) nanoparticles (NPs) that act as a molecular imaging agent for liver malignancies. We hypothesized that, after intravenous administration, SERS NPs would avidly home to healthy liver tissue but not to intrahepatic malignancies. We tested these SERS NPs in genetically engineered mouse models of hepatocellular carcinoma and histiocytic sarcoma. After intravenous injection, liver tumors in both models were readily identifiable with Raman imaging. In addition, Raman imaging using SERS NPs enabled detection of microscopic lesions in liver and spleen. We compared the performance of SERS NPs to fluorescence imaging using indocyanine green (ICG). We found that SERS NPs delineate tumors more accurately and are less susceptible to photobleaching. Given the known advantages of SERS imaging, namely, high sensitivity and specific spectroscopic detection, these findings hold promise for improved resection of liver cancer. Complete surgical resection is the ideal first-line treatment for most liver malignancies. This goal would be facilitated by an intraoperative imaging method that enables more precise visualization of tumor margins and detection of otherwise invisible microscopic lesions. To this end, we synthesized silica-encapsulated surface-enhanced Raman scattering (SERS) nanoparticles (NPs) that act as a molecular imaging agent for liver malignancies. We hypothesized that, after intravenous administration, SERS NPs would avidly home to healthy liver tissue but not to intrahepatic malignancies. We tested these SERS NPs in genetically engineered mouse models of hepatocellular carcinoma and histiocytic sarcoma. After intravenous injection, liver tumors in both models were readily identifiable with Raman imaging. In addition, Raman imaging using SERS NPs enabled detection of microscopic lesions in liver and spleen. We compared the performance of SERS NPs to fluorescence imaging using indocyanine green (ICG). We found that SERS NPs delineate tumors more accurately and are less susceptible to photobleaching. Given the known advantages of SERS imaging, namely, high sensitivity and specific spectroscopic detection, these findings hold promise for improved resection of liver cancer.Complete surgical resection is the ideal first-line treatment for most liver malignancies. This goal would be facilitated by an intraoperative imaging method that enables more precise visualization of tumor margins and detection of otherwise invisible microscopic lesions. To this end, we synthesized silica-encapsulated surface-enhanced Raman scattering (SERS) nanoparticles (NPs) that act as a molecular imaging agent for liver malignancies. We hypothesized that, after intravenous administration, SERS NPs would avidly home to healthy liver tissue but not to intrahepatic malignancies. We tested these SERS NPs in genetically engineered mouse models of hepatocellular carcinoma and histiocytic sarcoma. After intravenous injection, liver tumors in both models were readily identifiable with Raman imaging. In addition, Raman imaging using SERS NPs enabled detection of microscopic lesions in liver and spleen. We compared the performance of SERS NPs to fluorescence imaging using indocyanine green (ICG). We found that SERS NPs delineate tumors more accurately and are less susceptible to photobleaching. Given the known advantages of SERS imaging, namely, high sensitivity and specific spectroscopic detection, these findings hold promise for improved resection of liver cancer. Complete surgical resection is the first-line treatment for most liver malignancies. This goal would be facilitated by an intraoperative imaging method that enables more precise visualization of tumor margins, and detection of otherwise invisible microscopic lesions. To this end, we synthesized silica-encapsulated surface-enhanced Raman scattering (SERS) nanoparticles (NPs) that act as a molecular imaging agent for liver malignancies. We hypothesized that, after intravenous administration, SERS NPs would avidly home to healthy liver tissue, but not to intrahepatic malignancies. We tested these SERS NPs in genetically engineered mouse models of hepatocellular carcinoma and histiocytic sarcoma. After intravenous injection, liver tumors in both models were readily identifiable with Raman imaging. In addition, Raman imaging using SERS NPs enabled detection of microscopic lesions in liver and spleen. We compared the performance of SERS NPs to fluorescence imaging using Indocyanine Green (ICG). We found that SERS NPs delineate tumors more accurately and are less susceptible to photobleaching. Given the known advantages of SERS imaging, namely high sensitivity and specific spectroscopic detection, these findings hold promise for improved resection of liver cancer. |
| Author | Mannelli, Lorenzo Neuschmelting, Volker Colen, Rivka R Kircher, Moritz F Lowe, Scott W Karabeber, Hazem Huang, Chun-Hao Andreou, Chrysafis Tschaharganeh, Darjus-Felix Oseledchyk, Anton Iacono, Pasquale |
| AuthorAffiliation | Department of Radiology, M.D. Anderson Cancer Center Howard Hughes Medical Institute Cancer Biology and Genetics Program University of Texas Center for Molecular Imaging and Nanotechnology (CMINT) Memorial Sloan Kettering Cancer Center Weill Cornell Medical College Department of Radiology |
| AuthorAffiliation_xml | – name: Department of Radiology – name: Weill Cornell Medical College – name: Department of Radiology, M.D. Anderson Cancer Center – name: University of Texas – name: Memorial Sloan Kettering Cancer Center – name: Center for Molecular Imaging and Nanotechnology (CMINT) – name: Howard Hughes Medical Institute – name: Cancer Biology and Genetics Program – name: 1 Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – name: 2 Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – name: 6 Department of Radiology, Weill Cornell Medical College, New York, NY 10065, USA – name: 5 Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – name: 4 Howard Hughes Medical Institute, New York, NY 10065, USA – name: 3 Department of Radiology, M.D. Anderson Cancer Center, University of Texas, Houston, Texas, 77030, USA |
| Author_xml | – sequence: 1 givenname: Chrysafis surname: Andreou fullname: Andreou, Chrysafis – sequence: 2 givenname: Volker surname: Neuschmelting fullname: Neuschmelting, Volker – sequence: 3 givenname: Darjus-Felix surname: Tschaharganeh fullname: Tschaharganeh, Darjus-Felix – sequence: 4 givenname: Chun-Hao surname: Huang fullname: Huang, Chun-Hao – sequence: 5 givenname: Anton surname: Oseledchyk fullname: Oseledchyk, Anton – sequence: 6 givenname: Pasquale surname: Iacono fullname: Iacono, Pasquale – sequence: 7 givenname: Hazem surname: Karabeber fullname: Karabeber, Hazem – sequence: 8 givenname: Rivka R surname: Colen fullname: Colen, Rivka R – sequence: 9 givenname: Lorenzo surname: Mannelli fullname: Mannelli, Lorenzo – sequence: 10 givenname: Scott W surname: Lowe fullname: Lowe, Scott W – sequence: 11 givenname: Moritz F surname: Kircher fullname: Kircher, Moritz F email: kircherm@mskcc.org |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27078225$$D View this record in MEDLINE/PubMed |
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| Snippet | Complete surgical resection is the ideal first-line treatment for most liver malignancies. This goal would be facilitated by an intraoperative imaging method... Complete surgical resection is the first-line treatment for most liver malignancies. This goal would be facilitated by an intraoperative imaging method that... |
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| SubjectTerms | Animals Carcinoma, Hepatocellular - diagnostic imaging Liver Neoplasms - diagnostic imaging Nanoparticles Silicon Dioxide Spectrum Analysis, Raman |
| Title | Imaging of Liver Tumors Using Surface-Enhanced Raman Scattering Nanoparticles |
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