Matrix sublimation/recrystallization for imaging proteins by mass spectrometry at high spatial resolution

We have employed matrix deposition by sublimation for protein image analysis on tissue sections using a hydration/recrystallization process that produces high-quality MALDI mass spectra and high-spatial-resolution ion images. We systematically investigated different washing protocols, the effect of...

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Bibliographic Details

Published in:	Analytical chemistry (Washington) Vol. 83; no. 14; p. 5728
Main Authors:	Yang, Junhai, Caprioli, Richard M
Format:	Journal Article
Language:	English
Published:	United States 15.07.2011
Subjects:	Animals Brain - ultrastructure Brain Chemistry Chickens Crystallization Histological Techniques - methods Liver - chemistry Mice Proteins - analysis Rats Sensitivity and Specificity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
ISSN:	1520-6882, 1520-6882
Online Access:	Get more information
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