Development of Oral, Potent, and Selective CK1α Degraders for AML Therapy

Molecular glue degraders (MGDs) are proximity-inducing agents that mediate the cooperative interaction between a target protein and an E3 ligase, introducing an additional layer of specificity beyond that afforded by traditional small molecules. Historically, molecular glues that stabilize protein–p...

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Bibliographic Details

Published in:	JACS Au Vol. 4; no. 11; pp. 4423 - 4434
Main Authors:	Huang, Lu, Chen, Lu, Peng, Bo, Zhou, Lixin, Sun, Yanli, Shi, Taiting, Lu, Jiayi, Lin, Weiye, Liu, Yuhang, Cao, Linhui, Li, Lanlan, Han, Qiangqiang, Chen, Xi, Yang, Ping, Zhang, Shuo, Wang, Zhe, Yang, Jing, Guo, Zhixiang, Jiang, Baishan, Lu, Wenchao
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 25.11.2024
Subjects:	AML molecular glue degrader CK1α induced proximity P53
ISSN:	2691-3704, 2691-3704
Online Access:	Get full text
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