Dynamic behavior of the p53-Mdm2 core module under the action of drug Nutlin and dual delays

Nutlin is a family of p53-targeting drugs. It is able to bind to Mdm2, thereby accelerate the accumulation of p53 that is a prominent tumor suppressor. An integrated module of the Nutlin PBK and p53 pathway is composed of positive feedback mediated by Mdm2 mRNA as well as the drug Nutlin and negativ...

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Bibliographic Details
Published in:	Mathematical biosciences and engineering : MBE Vol. 18; no. 4; pp. 3448 - 3468
Main Authors:	Yang, Juenu, Yan, Fang, Liu, Haihong
Format:	Journal Article
Language:	English
Published:	United States AIMS Press 01.01.2021
Subjects:	Apoptosis Cell Line, Tumor Computer Simulation drug nutlin Feedback hopf bifurcation Humans Imidazoles - pharmacology p53 signal pathway Pharmaceutical Preparations Piperazines - pharmacology Proto-Oncogene Proteins c-mdm2 - metabolism time delays Tumor Suppressor Protein p53 time delays Hopf bifurcation drug Nutlin p53 signal pathway
ISSN:	1551-0018, 1551-0018
Online Access:	Get full text
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