A group of segmented viruses contains genome segments sharing homology with multiple viral taxa

Metaviromics has greatly expanded our understanding of viral diversity, including segmented or multipartite RNA viruses with genomes composed of multiple segments. However, virome analyses often fail to detect genomic segments beyond the RdRP, likely due to their low similarity to known viruses. We...

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Published in:Journal of virology Vol. 99; no. 7; p. e0033225
Main Authors: Huang, Huang, Zhang, Zhongmei, Pang, Xidan, Tang, Qing, Xiao, Xueqiong, Cheng, Jiasen, Fu, Yanping, Lin, Yang, Chen, Tao, Li, Bo, Zhang, Lei, Jiang, Daohong, Xie, Jiatao
Format: Journal Article
Language:English
Published: United States American Society for Microbiology 22.07.2025
Subjects:
Evolution, Molecular
Fungal Viruses - classification
Fungal Viruses - genetics
Fusarium - virology
Genetic Diversity and Evolution
genome segmentation
Genome, Viral
mycovirus
Phylogeny
RNA Viruses - classification
RNA Viruses - genetics
RNA, Viral - genetics
rod-shaped virion
segmented virus
Viral Proteins - genetics
Virology
mycovirus
genome segmentation
rod-shaped virion
segmented virus
ISSN:0022-538X, 1098-5514, 1098-5514
Online Access:Get full text
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Summary:Metaviromics has greatly expanded our understanding of viral diversity, including segmented or multipartite RNA viruses with genomes composed of multiple segments. However, virome analyses often fail to detect genomic segments beyond the RdRP, likely due to their low similarity to known viruses. We characterized a group of segmented, potentially multipartite, +ssRNA viruses, with Fusarium asiaticum vivivirus 1 as a representative; most of these viruses likely infect fungi. Through structural and evolutionary analysis of the five core segments of viviviruses, our findings highlight key aspects of vivivirus evolution, including genome segmentation, gene and domain duplications, and segments with multiple evolutionary origins.
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Huang Huang and Zhongmei Zhang contributed equally to this article. The author order was determined based on alphabetical order of surname.
The authors declare no conflict of interest.
ISSN:0022-538X
1098-5514
1098-5514
DOI:10.1128/jvi.00332-25